Proteasome inhibition improves diaphragm function in congestive heart failure rats.

American Journal of Physiology. Lung Cellular and Molecular Physiology
Hieronymus W H van HeesLeo M A Heunks

Abstract

In congestive heart failure (CHF), diaphragm weakness is known to occur and is associated with myosin loss and activation of the ubiquitin-proteasome pathway. The effect of modulating proteasome activity on myosin loss and diaphragm function is unknown. The present study investigated the effect of in vivo proteasome inhibition on myosin loss and diaphragm function in CHF rats. Coronary artery ligation was used as an animal model for CHF. Sham-operated rats served as controls. Animals were treated with the proteasome inhibitor bortezomib (intravenously) or received saline (0.9%) injections. Force generating capacity, cross-bridge cycling kinetics, and myosin content were measured in diaphragm single fibers. Proteasome activity, caspase-3 activity, and MuRF-1 and MAFbx mRNA levels were determined in diaphragm homogenates. Proteasome activities in the diaphragm were significantly reduced by bortezomib. Bortezomib treatment significantly improved diaphragm single fiber force generating capacity (approximately 30-40%) and cross-bridge cycling kinetics (approximately 20%) in CHF. Myosin content was approximately 30% higher in diaphragm fibers from bortezomib-treated CHF rats than saline. Caspase-3 activity was decreased in diaphragm ...Continue Reading

References

Apr 1, 1979·Circulation Research·M A PfefferE Braunwald
May 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·B Brenner, E Eisenberg
May 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·B Brenner
Jul 1, 1980·Analytical Biochemistry·B R OakleyN R Morris
Apr 1, 1980·Proceedings of the National Academy of Sciences of the United States of America·A HershkoI A Rose
Feb 4, 1997·Proceedings of the National Academy of Sciences of the United States of America·H C Drexler
Jul 1, 1997·The Journal of Clinical Investigation·N E TawaA L Goldberg
Oct 6, 1997·The European Respiratory Journal·G C Sieck, Y S Prakash
Oct 24, 1997·Journal of Applied Physiology·W J PerkinsG C Sieck
Oct 15, 1998·Proceedings of the National Academy of Sciences of the United States of America·V SolomonA L Goldberg
Jan 1, 1999·Bioorganic & Medicinal Chemistry Letters·J AdamsR L Stein
Aug 3, 1999·American Journal of Respiratory and Critical Care Medicine·P D HughesM Green
Aug 5, 2000·Journal of Applied Physiology·P C GeigerG C Sieck
Jun 16, 2001·Journal of Cellular Biochemistry·S A ShahM P Callery
Aug 22, 2001·Chemistry & Biology·A F Kisselev, A L Goldberg
Oct 20, 2001·Journal of Applied Physiology·L M HeunksG C Sieck
Nov 5, 2002·Nature Reviews. Cancer·Michael J Tisdale
May 10, 2003·Cancer Treatment Reviews·Julian Adams
Jun 21, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Lan V PhamRichard J Ford
Jun 27, 2003·The New England Journal of Medicine·Paul G RichardsonKenneth C Anderson
Jan 1, 2004·The Journal of Clinical Investigation·Jie DuWilliam E Mitch
Aug 3, 2004·The Journal of Clinical Investigation·Swarnali AcharyyaDenis C Guttridge
Jan 15, 2005·The Journal of Clinical Investigation·Yao-Hua SongPatrick Delafontaine
Mar 5, 2005·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Yi-Ping LiMichael B Reid
Apr 26, 2005·American Journal of Respiratory and Critical Care Medicine·Coen A C OttenheijmP N Richard Dekhuijzen
Jul 28, 2005·American Journal of Physiology. Endocrinology and Metabolism·Brian J KrawiecCharles H Lang
Feb 16, 2006·Molecular and Cellular Biology·Dennis SohnReiner U Jänicke
Mar 4, 2006·Experimental Biology and Medicine·Blake C BeehlerGary J Grover
Jun 2, 2006·Journal of the American Society of Nephrology : JASN·Stewart H LeckerWilliam E Mitch
Jun 17, 2006·Current Opinion in Clinical Nutrition and Metabolic Care·Oliver Friedrich
Aug 19, 2006·American Journal of Respiratory and Critical Care Medicine·Coen A C OttenheijmP N Richard Dekhuijzen
Sep 2, 2006·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Charles H LangRobert A Frost
Oct 17, 2006·American Journal of Physiology. Heart and Circulatory Physiology·Catherine CoiraultYves Lecarpentier
Nov 8, 2006·Annals of Internal Medicine·Eyal Reinstein, Aaron Ciechanover
Dec 7, 2006·American Journal of Physiology. Endocrinology and Metabolism·Carmen M BastidaRafael Peñafiel
Jan 16, 2007·Journal of Applied Physiology·Gerald S SupinskiLeigh A Callahan
Mar 24, 2007·American Journal of Respiratory and Critical Care Medicine·Karen MaesGhislaine Gayan-Ramirez
Apr 24, 2007·American Journal of Physiology. Heart and Circulatory Physiology·Hieronymus W H van HeesP N Richard Dekhuijzen
May 15, 2007·Chest·William D Schweickert, Jesse Hall
Jun 9, 2007·Journal of Applied Physiology·Gary C SieckY S Prakash

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Citations

Sep 2, 2010·Cell Research·Hongbiao HuangJinbao Liu
Apr 21, 2009·American Journal of Physiology. Lung Cellular and Molecular Physiology·G S SupinskiL A Callahan
Jun 13, 2009·Journal of Applied Physiology·Heather M ArgadineGary C Sieck
Dec 7, 2010·American Journal of Respiratory and Critical Care Medicine·Frances S de ManCoen A C Ottenheijm
Nov 12, 2013·Journal of Cardiothoracic Surgery·Liu JianYuan Zhongxiang
Oct 1, 2011·Critical Care : the Official Journal of the Critical Care Forum·Hieronymus W H van HeesLeo M A Heunks
Jun 16, 2012·International Journal of Medical Sciences·Qiang JiYunqing Mei
Feb 11, 2014·Critical Care : the Official Journal of the Critical Care Forum·Willem-Jan M SchellekensLeo M A Heunks
Mar 30, 2010·Journal of Molecular Histology·Robson Francisco CarvalhoMaeli Dal Pai-Silva
Dec 18, 2015·Journal of Cachexia, Sarcopenia and Muscle·Norman MangnerVolker Adams
Jan 20, 2009·International Journal of Cardiology·H W H van HeesL M A Heunks
Jun 26, 2013·Journal of Cachexia, Sarcopenia and Muscle·Dirk HabedankRalf Ewert
Apr 20, 2016·Critical Care : the Official Journal of the Critical Care Forum·Willem-Jan M SchellekensLeo M A Heunks
Oct 19, 2016·Medicine and Science in Sports and Exercise·Norman MangnerVolker Adams
Oct 22, 2016·Medizinische Klinik, Intensivmedizin und Notfallmedizin·C S Bruells, G Marx
Jun 27, 2015·The European Respiratory Journal·Emmy MandersFrances S de Man
Jul 20, 2012·Critical Care Medicine·Anouk AgtenGhislaine Gayan-Ramirez
Sep 22, 2016·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·T Scott BowenVolker Adams
Apr 5, 2011·American Journal of Physiology. Lung Cellular and Molecular Physiology·Hieronymus van HeesLeo Heunks
Sep 13, 2019·Expert Opinion on Therapeutic Targets·Esther BarreiroJun Tang
Jan 1, 2017·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·T Scott BowenVolker Adams
Jul 8, 2020·International Journal of Molecular Sciences·Mattia ScalabrinT Scott Bowen
Feb 5, 2021·Circulation Research·Norman MangnerVolker Adams

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