Proteasomes: structure and biology

Journal of Biochemistry
K Tanaka

Abstract

The proteasome is a multisubunit protease complex with an apparent sedimentation coefficient of 20S. Two types of regulatory complexes, named PA700 and PA28, bind to both ends of the cylindrical 20S proteasome to form the dumbbell-like and football-like proteasomes, respectively. The former complex, named the 26S proteasome, is a eukaryotic ATP-dependent protease and appears to be well organized as a large complex of 2 MDa, consisting of approximately 40 polypeptides, to facilitate rapid proteolysis. It is assumed to be a protein "death machine", destroying a variety of cellular proteins that have acquired a specific degradation signal(s) such as a multiubiquitin chain. Recently data on in vivo substrates for the ubiquitin-proteasome pathway have been accumulating rapidly, implying its involvement in many biologically important processes, such as cell-cycle regulation, signal transduction, protein quality control, and the immune response. The newly-identified PA28 family proteins are inducible by interferons, and may cooperate with the 26S proteasome or play additional roles. Since the proteasome is capable of catalyzing breakdown of proteins not only irreversibly, but also rapidly and timely, it is thought to be a new regulato...Continue Reading

Citations

Feb 15, 2001·Biopolymers·K ChaturvediR D Howells
Aug 10, 2000·Journal of Neuroscience Research·J N Keller, W R Markesbery
Jan 9, 2001·Archives of Biochemistry and Biophysics·S WilkR P Magnusson
Mar 24, 2004·Archives of Medical Research·Miguel CruzJesús Kumate
Jan 27, 2004·Bioorganic & Medicinal Chemistry Letters·Masayuki InoueMasahiro Hirama
Mar 10, 2005·Experimental Parasitology·R Guerra-SáV Rodrigues
Jul 19, 2003·Metabolism: Clinical and Experimental·Frederick G HamelWilliam C Duckworth
Apr 20, 2001·Mechanisms of Ageing and Development·M GaczynskaW F Ward
Mar 9, 2000·Mechanisms of Ageing and Development·J N KellerW R Markesbery
Jul 20, 1999·Molecular and Cellular Endocrinology·I PirsonD Perez-Morga
Jan 16, 2002·Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP·E TanakaH Sawada
Nov 21, 2000·Free Radical Biology & Medicine·J N KellerW F Maragos
Aug 28, 2001·Free Radical Biology & Medicine·Q Ding, J N Keller
Jun 8, 2001·Bioorganic & Medicinal Chemistry Letters·C García-EcheverríaP Furet
Mar 10, 2004·The International Journal of Biochemistry & Cell Biology·Naoyuki SakaiHitoshi Sawada
Jun 1, 2002·Ageing Research Reviews·Jeffrey N KellerQunxing Ding
Apr 24, 2012·Chemical Reviews·Reem SmoumMorris Srebnik
Nov 3, 1998·Genes to Cells : Devoted to Molecular & Cellular Mechanisms·K Tanaka, T Chiba
Jun 9, 2000·International Journal of Andrology·C WojcikJ F Guerin
Jun 10, 2000·Scandinavian Journal of Immunology·B W MurrayJ Klein
Apr 12, 2001·European Journal of Biochemistry·M MinamiY Minami
Jun 15, 2000·Journal of Neurochemistry·J N KellerW R Markesbery
Jan 14, 2010·The Journal of Biological Chemistry·Suzanne KapetaEfstathios S Gonos
Sep 19, 2002·Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan·Hiroyuki Kawahara
Apr 4, 2002·Japanese Journal of Pharmacology·Mamoru OhkitaYasuo Matsumura
May 30, 2002·Biological Chemistry·Jana Mehlhase, Tilman Grune
May 16, 2002·Zoological Science·Hitoshi Sawada
Jan 16, 2009·Proceedings of the Japan Academy. Series B, Physical and Biological Sciences·Keiji Tanaka
Jul 14, 2012·Case Reports in Surgery·Suhail Yaqoob HakeemRajandeep Singh Bali
Dec 19, 2000·Biochemical and Biophysical Research Communications·S YokotaH Kubota
Jul 26, 2000·Proceedings of the National Academy of Sciences of the United States of America·A DaceS Cheng
Nov 30, 2002·Journal of Cataract and Refractive Surgery·Junko NakajimaYoshimitsu Tokunaga

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