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Protect from light: photodegradation and protein biologics

Journal of Pharmaceutical Sciences

Jan 19, 2007

Bruce A Kerwin, Richard L Remmele

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Abstract

The exposure of proteins to light and the ensuing chemical and physical degradation has been studied extensively for many years. The residues in proteins that undergo primary photooxidation include tryptophan, tyrosine, phenylalanine, and cysteine/cystine. While photooxidation has been ...read more

Mentioned in this Paper

Biochemical Pathway
Tryptophan
Protein Degradation, Regulatory
Biological Products
Natural Products
Photodegradation
Protein Degradation, Metabolic
Spur (Body Structure)
PMS-Tryptophan
Cysteine
Paper Details
References
  • References22
  • Citations80
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  • References22
  • Citations80
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Protect from light: photodegradation and protein biologics

Journal of Pharmaceutical Sciences

Jan 19, 2007

Bruce A Kerwin, Richard L Remmele

PMID: 17230445

DOI: 10.1002/jps.20815

Abstract

The exposure of proteins to light and the ensuing chemical and physical degradation has been studied extensively for many years. The residues in proteins that undergo primary photooxidation include tryptophan, tyrosine, phenylalanine, and cysteine/cystine. While photooxidation has been ...read more

Mentioned in this Paper

Biochemical Pathway
Tryptophan
Protein Degradation, Regulatory
Biological Products
Natural Products
Photodegradation
Protein Degradation, Metabolic
Spur (Body Structure)
PMS-Tryptophan
Cysteine

Feeds With Similar Papers

Collaboration for AIDS Vaccine Discovery (ASM)

Collaboration for AIDS Vaccine Discovery (CAVD)

Collaboration for AIDS Vaccine Discovery (CAVD)

The Collaboration for AIDS Vaccine Discovery (CAVD) focuses on designing a variety of novel HIV vaccine candidates and advancing the most promising candidates to clinical trials. Follow this feed to stay up to date on this important research from the CAVD.

Related Papers

Journal of Photochemistry and Photobiology. B, Biology

Photo-oxidation of proteins and its role in cataractogenesis

Journal of Photochemistry and Photobiology. B, BiologyOctober 31, 2001
M J Davies, R J Truscott
Paper Details
References
  • References22
  • Citations80
123
  • References22
  • Citations80
12345...

Download from

Publisher
PubMed
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