Protecting the aged heart during cardiac surgery: the potential benefits of del Nido cardioplegia

The Journal of Thoracic and Cardiovascular Surgery
Stacy B O'BlenesSusan E Howlett

Abstract

Aged hearts are more vulnerable than mature hearts to reperfusion injury during cardiac surgery because of altered cardiomyocyte Ca(2+) homeostasis. Inasmuch as immature cardiomyocytes have similar properties, a specialized cardioplegic solution (del Nido cardioplegia) designed to protect children's hearts may also be beneficial for elderly patients. Our objective was to evaluate the ability of del Nido cardioplegic solution, containing lidocaine and less Ca(2+) than our standard cardioplegic solution, to protect aged cardiomyocytes during cardioplegic arrest and reperfusion. We used our novel isolated cell model of cardioplegic arrest and reperfusion to compare the effect of del Nido cardioplegic solution with that of our standard cardioplegic solution on intracellular Ca(2+) concentration, contractions, and membrane potential in cardiomyocytes from senescent rat hearts. The incidence of spontaneous contractions during cardioplegic arrest was lower with del Nido cardioplegia (3/11 vs 9/11 cells; P < .05) than with standard cardioplegia, and contractions could not be induced by field stimulation of cardiomyocytes arrested with del Nido cardioplegia (0/11 vs 9/11 cells; P < .05). Intracellular diastolic Ca(2+) levels were lower ...Continue Reading

References

Mar 16, 1979·Pflügers Archiv : European journal of physiology·D AttwellC Ojeda
May 1, 1983·The Journal of General Physiology·B P BeanR W Tsien
Feb 1, 1995·The Journal of Thoracic and Cardiovascular Surgery·C A CaldaroneS Levitsky
Dec 10, 1999·The Annals of Thoracic Surgery·H M Piper, D García-Dorado
May 16, 2000·Chest·H HiroseT Kohmoto
Apr 20, 2001·Seminars in Thoracic and Cardiovascular Surgery·B S AllenM N Ilbawi
Feb 28, 2003·The Annals of Thoracic Surgery·David J Chambers
Feb 9, 2005·Journal of Molecular and Cellular Cardiology·Laura WillemsJohn P Headrick
Feb 19, 2005·Circulation Research·Rodolphe P Katra, Kenneth R Laurita
May 16, 2006·American Journal of Physiology. Heart and Circulatory Physiology·Robin H ShuttSusan E Howlett
Mar 11, 2008·American Journal of Physiology. Heart and Circulatory Physiology·J Darcy O'BrienSusan E Howlett
Apr 22, 2009·The Annals of Thoracic Surgery·J Darcy O'BrienCamille L Hancock Friesen
Jul 9, 2009·The Annals of Thoracic Surgery·David M ShahianUNKNOWN Society of Thoracic Surgeons Quality Measurement Task Force

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Citations

Apr 4, 2013·Journal of Cardiothoracic Surgery·Sarkis M MinasianTimur D Vlasov
Aug 21, 2013·The Journal of Thoracic and Cardiovascular Surgery·Arun GovindapillaiStacy B O'Blenes
Feb 24, 2015·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·Kristinn ThorsteinssonJan J Andreasen
Nov 28, 2015·Journal of Cardiothoracic Surgery·Marc NajjarMathew R Williams
May 28, 2014·Journal of Cardiac Surgery·Robert A SorabellaIsaac George
Jul 23, 2015·Journal of Cardiac Surgery·Maroun YammineSary F Aranki
Mar 3, 2015·The Journal of Thoracic and Cardiovascular Surgery·Niv Ad
Dec 9, 2014·The Journal of Thoracic and Cardiovascular Surgery·Stephanie L MickJoseph F Sabik
Jul 3, 2016·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·Gerald D Buckberg, Constantine L Athanasuleas
Sep 15, 2016·Clinical and Experimental Pharmacology & Physiology·Alice E Kane, Susan E Howlett
Dec 26, 2017·Hospital Pharmacy·Luis M PereiraAl Patterson
Feb 17, 2018·Interactive Cardiovascular and Thoracic Surgery·Wan Kee KimJae Won Lee
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Oct 11, 2017·Innovations : Technology and Techniques in Cardiothoracic and Vascular Surgery·Raphael HamadPhilippe Demers
Feb 15, 2019·Journal of Cardiac Surgery·Sotiris C StamouMarcos A Nores
Feb 21, 2018·Journal of Cardiac Surgery·Michael S KoeckertEugene A Grossi
Dec 12, 2018·Circulation Journal : Official Journal of the Japanese Circulation Society·Christian O'DonnellJack H Boyd
May 10, 2020·BMC Cardiovascular Disorders·Mohamed MarzoukFrederic Jacques
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