Protecting your tail: regulation of cadherin degradation by p120-catenin

Current Opinion in Cell Biology
Andrew P Kowalczyk, Albert B Reynolds

Abstract

Work in various model systems has yielded conflicting views of how p120-catenin participates in adherens junction assembly and regulation. A series of recent studies indicate that a core function of p120-catenin in mammalian cells is to regulate cadherin turnover by modulating the entry of cadherins into degradative endocytic pathways. By this mechanism, cellular levels of p120-catenin perform a 'rheostat' or 'set point' function that controls steady-state cadherin levels. These studies parallel a growing interest in the regulation of cadherin levels at the cell surface by membrane trafficking pathways. Collectively, the findings suggest exciting new roles for p120-catenin at the interface between cadherins and membrane trafficking machinery, and imply novel mechanisms by which p120-catenin may regulate cell adhesion and migration in the context of development and cancer.

References

Jul 14, 1999·The Journal of Cell Biology·T L LeJ L Stow
Jan 12, 2000·The Journal of Cell Biology·M A ThoresonA B Reynolds
Apr 11, 2001·Molecular Biology of the Cell·N Akhtar, N A Hotchin
Sep 7, 2001·Current Opinion in Cell Biology·P Z Anastasiadis, A B Reynolds
Feb 12, 2002·Nature Cell Biology·Yasuyuki FujitaWalter Birchmeier
Jul 11, 2002·American Journal of Physiology. Cell Physiology·Tam Luan LeJennifer L Stow
Sep 17, 2002·Current Opinion in Cell Biology·David R GarrodZhuxiang Nie
Nov 13, 2002·The Journal of Cell Biology·Renee C IretonAlbert B Reynolds
Nov 26, 2002·Nature Cell Biology·Felipe PalaciosCrislyn D'Souza-Schorey
Dec 21, 2002·Differentiation; Research in Biological Diversity·Molly A Thoreson, Albert B Reynolds
Jan 29, 2003·The Journal of Cell Biology·Anne PacqueletPernille Rorth
Mar 11, 2003·The Journal of Biological Chemistry·Kanyan XiaoAndrew P Kowalczyk
Sep 4, 2003·Journal of Cell Science·Agnes Roczniak-Ferguson, Albert B Reynolds
Oct 23, 2003·Annual Review of Cell and Developmental Biology·Margaret J Wheelock, Keith R Johnson
Nov 12, 2003·The Journal of Cell Biology·Michael A DavisAlbert B Reynolds
Dec 9, 2003·The Journal of Biological Chemistry·Clemens M Franz, Anne J Ridley
Dec 16, 2003·American Journal of Physiology. Lung Cellular and Molecular Physiology·Seema IyerPeter A Vincent
Dec 17, 2003·The Journal of Biological Chemistry·Masahiro YanagisawaPanos Z Anastasiadis
Mar 6, 2004·Science·W James Nelson, Roel Nusse
Apr 7, 2004·The Journal of Cell Biology·Xiang FangPierre D McCrea
Apr 9, 2004·Nature Reviews. Molecular Cell Biology·Spiro GetsiosKathleen J Green
Apr 9, 2004·Nature Reviews. Molecular Cell Biology·Jean Gruenberg, Harald Stenmark
Aug 17, 2004·Trends in Cell Biology·David M Bryant, Jennifer L Stow
Nov 25, 2004·Seminars in Cell & Developmental Biology·Albert B Reynolds, Robert H Carnahan

❮ Previous
Next ❯

Citations

Apr 4, 2008·Histochemistry and Cell Biology·Jens Waschke
Aug 29, 2009·Nature Structural & Molecular Biology·Nicolas J LehrbachEric A Miska
Aug 27, 2005·Molecular Biology of the Cell·Kanyan XiaoAndrew P Kowalczyk
Jul 18, 2008·Molecular Biology of the Cell·Alexi KissSergey M Troyanovsky
Feb 26, 2010·Molecular Biology of the Cell·Mariana V HernándezCarlos O Arregui
Aug 28, 2007·Applied Immunohistochemistry & Molecular Morphology : AIMM·David J DabbsGloria J Carter
Feb 26, 2010·Cold Spring Harbor Perspectives in Biology·Kathleen J GreenL M Godsel
Jan 13, 2010·Cold Spring Harbor Perspectives in Biology·Pierre D McCreaMaria S Balda
May 5, 2010·Molecular and Cellular Biology·Oxana M TsygankovaJudy L Meinkoth
Sep 9, 2008·The Journal of Clinical Investigation·Masahiro MurakamiMichael Simons
Nov 13, 2007·BMC Developmental Biology·Allisan Aquilina-BeckJennifer O Liang
Nov 12, 2010·Breast Cancer Research : BCR·Angela IncassatiPamela Cowin
Feb 19, 2010·Journal of Cell Science·Pierre D McCrea, Dongmin Gu
Sep 29, 2012·Current Pharmaceutical Design·Andrey Voronkov, Stefan Krauss
Nov 14, 2006·Proceedings of the National Academy of Sciences of the United States of America·P Perez-PineraT F Deuel
Feb 1, 2006·Proceedings of the National Academy of Sciences of the United States of America·Yingxiao WangShu Chien
Jun 27, 2014·Molecular Biology of the Cell·Abbye E McEwenCara J Gottardi
Apr 6, 2005·The Journal of Cell Biology·Yang Luo, Glenn L Radice
Oct 22, 2008·Cell Communication & Adhesion·Matthew W CurtisMargaret J Wheelock
Dec 9, 2008·FEBS Letters·Julie Gavard
Mar 19, 2013·Experimental Cell Research·Masanori Nakayama, Philipp Berger
Sep 4, 2012·Journal of Biotechnology·Yuji KimuraMasao Washizu
Mar 23, 2011·Experimental Cell Research·Nicolas T ChartierMuriel R Jacquier-Sarlin
Aug 12, 2008·Biochimica Et Biophysica Acta·Megumi IiizumiKounosuke Watabe
Oct 16, 2007·Current Opinion in Cell Biology·Adam V KwiatkowskiW James Nelson
Jan 1, 2008·Experimental Cell Research·Jen-Chine WuWoei-Yau Kao
Feb 24, 2007·Pharmacology & Therapeutics·Walter C Prozialeck, Joshua R Edwards
Dec 1, 2006·Trends in Cell Biology·Ulrich Tepass, Kathryn P Harris
May 14, 2009·Cell Motility and the Cytoskeleton·Gang RenAlpha S Yap
Nov 8, 2011·Biology of the Cell·Armelle Le GuelteJulie Gavard
Aug 16, 2005·Current Opinion in Cell Biology·Jack Lilien, Janne Balsamo
Aug 7, 2008·Current Biology : CB·Eva M Kovacs, Alpha S Yap
Sep 1, 2006·Biochimica Et Biophysica Acta·Pierre D McCrea, Jae-Il Park
Oct 10, 2006·Biochimica Et Biophysica Acta·Panos Z Anastasiadis

❮ Previous
Next ❯

Related Concepts

Related Feeds

Adherens Junctions

An adherens junction is defined as a cell junction whose cytoplasmic face is linked to the actin cytoskeleton. They can appear as bands encircling the cell (zonula adherens) or as spots of attachment to the extracellular matrix (adhesion plaques). Adherens junctions uniquely disassemble in uterine epithelial cells to allow the blastocyst to penetrate between epithelial cells. Discover the latest research on adherens junctions here.

Cadherins and Catenins

Cadherins (named for "calcium-dependent adhesion") are a type of cell adhesion molecule (CAM) that is important in the formation of adherens junctions to bind cells with each other. Catenins are a family of proteins found in complexes with cadherin cell adhesion molecules of animal cells: alpha-catenin can bind to β-catenin and can also bind actin. β-catenin binds the cytoplasmic domain of some cadherins. Discover the latest research on cadherins and catenins here.

Calcium & Bioenergetics

Bioenergetic processes, including cellular respiration and photosynthesis, concern the transformation of energy by cells. Here is the latest research on the role of calcium in bioenergetics.

Anthelmintics

Anthelmintics or antihelminthics are a group of antiparasitic drugs that expel parasitic worms (helminths) and other internal parasites from the body by either stunning or killing them and without causing significant damage to the host. Discover the latest research on anthelmintics here.

Anthelmintics (ASM)

Anthelmintics or antihelminthics are a group of antiparasitic drugs that expel parasitic worms (helminths) and other internal parasites from the body by either stunning or killing them and without causing significant damage to the host. Discover the latest research on anthelmintics here.

Adhesion Molecules in Health and Disease

Cell adhesion molecules are a subset of cell adhesion proteins located on the cell surface involved in binding with other cells or with the extracellular matrix in the process called cell adhesion. In essence, cell adhesion molecules help cells stick to each other and to their surroundings. Cell adhesion is a crucial component in maintaining tissue structure and function. Discover the latest research on adhesion molecule and their role in health and disease here.

Related Papers

The Journal of Cell Biology
Michael A DavisAlbert B Reynolds
Biochimica Et Biophysica Acta
Kanyan XiaoAndrew P Kowalczyk
Molecular Biology of the Cell
Kanyan XiaoAndrew P Kowalczyk
© 2021 Meta ULC. All rights reserved