Protection afforded by preconditioning to the diabetic heart against ischaemic injury

Cardiovascular Research
J F Bouchard, D Lamontagne

Abstract

The aim of this study was to assess whether the cardioprotective effect of ischaemic preconditioning (IPC) on endothelial function in coronary arteries and myocardial function is affected in the streptozotocin-induced diabetic rat heart. Isolated hearts, perfused under constant flow conditions, were exposed to 30 min of partial ischaemia (flow rate 1 ml min-1) followed by 20 min of reperfusion. In the diabetic group (without ischaemia or IPC), infusion of 10 microM serotonin (5-HT), an endothelium-dependent, and 3 microM sodium nitroprusside (SNP), an endothelium-independent vasodilator, in the coronary bed preconstricted with 0.1 microM U-46619 induced a marked vasodilation. Ischaemia, either without or with preconditioning with a single 5 min ischaemia and 10 min reperfusion (IPC1) before ischaemia, was accompanied by a reduced 5-HT-induced vasodilation in diabetic hearts. In contrast, IPC1 preserved the response to 5-HT in non-diabetic hearts. A more extensive IPC with 3 periods of 5 min ischaemia followed by 5 min reperfusion (IPC3) preserved the vasodilation produced by 5-HT in both diabetic and non-diabetic hearts. IPC3 increased the recovery of d P/dtmax and d P/dtmin during the 30 min ischaemic period and during reperfu...Continue Reading

Citations

Sep 29, 2000·Pharmacology & Therapeutics·J W de JongS Bradamante
Jun 1, 2013·Cardiovascular Research·Hannah J WhittingtonDerek M Yellon
Mar 31, 2012·Cardiology Research and Practice·Hannah J WhittingtonDerek J Hausenloy
Oct 27, 2007·Redox Report : Communications in Free Radical Research·Vladimir VinokurMordechai Chevion
Sep 10, 2014·Cardiovascular Diabetology·Ruduwaan SalieAmanda Lochner
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Feb 24, 2019·Cardiovascular Research·Derek J HausenloyDavid Garcia-Dorado
Dec 25, 2012·Journal of Cardiovascular Pharmacology and Therapeutics·Derek J HausenloyDerek M Yellon

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