Protection against acid pulmonary aspiration with cimetidine

Anaesthesia and Intensive Care
J G Brock-utneJ Gjessing


Gastric pH values were studied prior to, and up to, ninety minutes after an intravenous injection of cimetidine 200 mg given before general anaesthesia, in twenty surgical patients, all with a gastric pH less than 3.5. At thirty, sixty and ninety minutes, sixteen, eighteen and twenty patients had a gastric pH greater than 3.5 respectively. In conclusion, the results of the present study indicate that cimetidine 200 mg given intravenously 90 minutes before surgery will reduce the hazard of chemical pneumonitis should stomach content be aspirated.


Sep 18, 1976·British Medical Journal·R J BaileyR Williams
Dec 1, 1978·British Journal of Anaesthesia·P J KeatingD W Watson
May 1, 1979·Anesthesia and Analgesia·D W CoombsT Colton
Jun 1, 1979·Anesthesiology·R G WheatleyA H Giesecke
Oct 1, 1979·British Journal of Anaesthesia·G DobbJ G Williams
May 1, 1975·British Journal of Anaesthesia·G Taylor
Oct 1, 1977·Archives of Surgery·R H Stewardson, L M Nyhus
Nov 2, 1978·The New England Journal of Medicine·W Finkelstein, K J Isselbacher
Nov 1, 1979·Anesthesiology·C P GibbsE J Kuck
Oct 1, 1978·British Journal of Anaesthesia·D B Scott
Nov 1, 1974·Anesthesia and Analgesia·R B Roberts, M A Shirley

Related Concepts

General Anesthesia
Gastric Acid
Hydrogen-Ion Concentration
Aspiration Pneumonia

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