PMID: 9523579Apr 2, 1998Paper

Protection against beta-amyloid toxicity in primary neurons by paclitaxel (Taxol)

Journal of Neurochemistry
Mary L MichaelisGunda Georg

Abstract

Neurofibrillary tangles in Alzheimer's disease contain aggregates of abnormally phosphorylated microtubule-associated protein tau, indicating that microtubule breakdown is a primary event in the neurodegenerative cascade. Recent studies have shown that addition to neuronal cultures of amyloid peptides found in Alzheimer's leads to abnormal phosphorylation of tau and neurofibrillary pathology. We tested the possibility that the microtubule-stabilizing drug paclitaxel (Taxol) might protect primary neurons against amyloid-induced toxicity. Neurons exposed to aggregated amyloid peptides 25-35 and 1-42 became pyknotic with degenerating neurites within 24 h. Treatment of cultures with paclitaxel either 2 h before or 2 h after addition of the peptide prevented these morphological alterations. When numbers of viable cells were determined in cultures exposed to amyloid peptide with or without paclitaxel for 24 or 96 h, the percentage of surviving cells was significantly higher in paclitaxel-treated cultures, and activation of the apoptosis-associated protease CPP32 was significantly reduced. These observations indicate that microtubule-stabilizing drugs may help slow development of the neurofibrillary pathology that leads to the loss of...Continue Reading

Citations

Mar 29, 2000·FEBS Letters·I BlaskoP Jansen-Dürr
Sep 6, 2002·Journal of Molecular Neuroscience : MN·Mary L MichaelisKenneth Audus
Feb 27, 2003·The Journal of Pharmacology and Experimental Therapeutics·Mary L Michaelis
Mar 6, 2015·Journal of Molecular Neuroscience : MN·Deyhim AtarodGholam Hossein Riazi
Sep 28, 2004·Journal of Neuroscience Research·Octavio Mercado-GómezClorinda Arias
Nov 9, 2011·Journal of Receptor and Signal Transduction Research·Su-Hua QiMin Wang
Jul 4, 2001·Journal of Neuroscience Research·J W AllenA I Faden
Sep 18, 2004·The Journal of Pharmacology and Experimental Therapeutics·M L MichaelisG I Georg
Apr 12, 2000·Journal of Neuropathology and Experimental Neurology·L A SelznickK A Roth
Mar 30, 2010·Journal of Neurochemistry·Ana Gabriela HenriquesOdete A B da Cruz E Silva
Dec 7, 2020·Drug Discovery Today·Zlata Boiarska, Daniele Passarella
Aug 10, 2006·Chemical Reviews·David W Christianson
Jan 16, 2014·Journal of Cell Science·Barbara PianuFrancesca Bartolini
Apr 1, 2000·Journal of Neuroimmunology·P Mukherjee, G M Pasinetti
Aug 17, 2002·Journal of Theoretical Biology·Leah Edelstein-keshet, Athan Spiros
Dec 24, 2004·Biochimica Et Biophysica Acta·Jeff KuretQi Zhong
Mar 6, 2007·European Journal of Pharmacology·David ButlerBen A Bahr
Nov 21, 2017·ACS Chemical Neuroscience·Prasenjit MondalSurajit Ghosh
Sep 1, 2009·Free Radical Biology & Medicine·Asma ZaidiMary L Michaelis
Aug 15, 2009·Biochemical Pharmacology·Kelly E DesinoKenneth L Audus

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