PMID: 2494118Mar 15, 1989Paper

Protection against chemically induced skin tumorigenesis in SENCAR mice by tannic acid

International Journal of Cancer. Journal International Du Cancer
Mukul DasH Mukhtar

Abstract

Tannic acid, a naturally occurring dietary polyphenol, was evaluated as a possible anticarcinogen in an initiation-and-promotion skin tumorigenesis protocol. In the 2-stage tumor protocol in SENCAR mice, using DMBA, BP and MNU as the initiating agents followed by twice-weekly applications of TPA as tumor promotor, tannic acid was found to be an effective inhibitor of tumor formation whether the tumor data are considered as cumulative number of tumors, percentage of mice with tumors or tumors/mouse. After 9 weeks of TPA application, the number of tumors/mouse in the groups receiving DMBA, BP and MNU were 32.10 +/- 3.18, 3.70 +/- 0.55 and 2.00 +/- 0.53, respectively, whereas the corresponding numbers in the DMBA, BP and MNU groups receiving prior applications of tannic acid were 11.50 +/- 2.38, 0.35 +/- 0.15 and 0.35 +/- 0.13, respectively. These results suggest that tannic acid may prove useful in reducing the risk of chemically-induced skin tumorigenesis.

Citations

Dec 1, 1994·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·H OnoderaY Hayashi
Jan 1, 1990·Drug Metabolism Reviews·J Kao, M P Carver
Jan 1, 1994·Journal of Obstetric, Gynecologic, and Neonatal Nursing : JOGNN·B L BuchkoD J Lerew
Oct 3, 2009·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Kausar M Ansari, Mukul Das
Jun 28, 2005·International Journal of Cancer. Journal International Du Cancer·Mukul DasSubhash K Khanna
Dec 29, 2006·Molecular Carcinogenesis·Sahar Al-Ayyoubi, Hala Gali-Muhtasib
Sep 13, 2008·Critical Reviews in Food Science and Nutrition·Martha R Bajec, Gary J Pickering
May 12, 2016·American Journal of Clinical Dermatology·Adilson CostaJack L Arbiser

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