Protection against cisplatin-induced ototoxicity by N-acetylcysteine in a rat model

Hearing Research
D Thomas DickeyEdward A Neuwelt

Abstract

Cisplatin (CDDP) is a widely used chemotherapeutic agent that is highly ototoxic. Animal studies and clinical trials have shown that thiosulfates can protect against platinum-induced ototoxicity. This study investigated a new model for CDDP ototoxicity in the rat, and tested the potential chemoprotective effect of administering N-acetylcysteine (NAC) before giving CDDP. Long Evans rats were treated with CDDP 6 mg/kg delivered to the aorta via a retrograde right external carotid artery infusion, 15 min after intravenous (IV) infusion of saline (n=8) or NAC 400 mg/kg (n=8), such that the vertebral arteries were perfused. Subsequent groups were similarly treated with NAC 30 min before (n=7) and 4 h after (n=7) CDDP. Auditory brainstem response (ABR) thresholds were tested at 4-20 kHz, 7 days after treatment and compared to baseline ABR values. The NAC-treated rats exhibited no significant change from baseline values at all time intervals, while the saline-treated rats showed marked ototoxicity, especially at higher frequencies. Furthermore, the rats treated with NAC 15 min before CDDP exhibited less overall toxicity to CDDP, as evidenced in weight loss 7 days post-treatment (mean for saline=-39.63 g; mean for NAC=-21.13 g; p=0.008...Continue Reading

References

Jan 1, 1990·Critical Reviews in Oncology/hematology·D R GandaraM W DeGregorio
Mar 1, 1985·Cancer·M S BlumenreichJ C Allegra
Jan 1, 1985·Archives of Oto-rhino-laryngology·K Böheim, E Bichler
Dec 1, 1982·Annals of Internal Medicine·S B HowellM Green
Jun 1, 1995·Pharmacology & Toxicology·R RaviL P Rybak
Jun 8, 2000·Annals of the New York Academy of Sciences·C Waters
Jun 8, 2000·Annals of the New York Academy of Sciences·D HendersonX Y Zheng
Jan 31, 2004·The Journal of Pharmacology and Experimental Therapeutics·Edward A NeuweltLeslie L Muldoon

❮ Previous
Next ❯

Citations

Oct 3, 2007·Cancer Chemotherapy and Pharmacology·D Thomas DickeyEdward A Neuwelt
Jul 5, 2008·Annals of Nuclear Medicine·Ozhan OzdoganHatice Durak
May 10, 2011·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Bulent TokgozCengiz Utas
May 2, 2012·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Penelope R BrockEdward A Neuwelt
Aug 2, 2011·Medical Science Monitor : International Medical Journal of Experimental and Clinical Research·Guiscardo LoritoHenryk Skarzynski
Oct 24, 2009·The Tohoku Journal of Experimental Medicine·Leonard P RybakVickram Ramkumar
Dec 4, 2013·Journal of the Association for Research in Otolaryngology : JARO·Jiwon ChangSung Won Chae
Aug 3, 2011·Journal of Controlled Release : Official Journal of the Controlled Release Society·Miyuki BabaTatsuya Yamasoba
Feb 26, 2008·Journal of Vascular and Interventional Radiology : JVIR·David A StenstromEdward A Neuwelt
Jun 20, 2006·Cancer Treatment Reviews·J H van den BergJ H M Schellens
Dec 19, 2015·Oxidative Medicine and Cellular Longevity·Nuria Mut-SaludFernando Rodríguez-Serrano
Jul 15, 2005·Hearing Research·Christopher Ton, Chuenlei Parng
Jul 31, 2014·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·Ismail KocyigitBulent Tokgoz
May 26, 2016·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·Hasan Emre KoçakBengül Altaş
Nov 30, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Kristin R Gilmer KnightEdward A Neuwelt
Aug 21, 2007·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Charlotte L ZuurAlfons J Balm
Mar 3, 2010·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Edward A Neuwelt, Penelope Brock
Aug 1, 2014·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·Shaulnie MohanMichael Anne Gratton
Feb 24, 2015·Experimental & Molecular Medicine·Se-Jin KimRaekil Park
Jan 11, 2007·Otology & Neurotology : Official Publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology·Dylan K ChanMichael G Kaplitt
Jul 12, 2007·Cytometry. Part a : the Journal of the International Society for Analytical Cytology·Shengli ShiTerrance J Kavanagh
Sep 8, 2007·Current Opinion in Otolaryngology & Head and Neck Surgery·Leonard P Rybak
Aug 22, 2013·Anti-cancer Drugs·Antonio RuggieroRiccardo Riccardi
Jun 14, 2005·The Journal of Pharmacology and Experimental Therapeutics·D Thomas DickeyEdward A Neuwelt
Oct 22, 2004·The Journal of Pharmacology and Experimental Therapeutics·Y Jeffrey WuEdward A Neuwelt
Nov 6, 2014·Experimental and Therapeutic Medicine·Fugen WangZhaobin Cai
Nov 21, 2014·Journal of Neuro-oncology·Leslie L MuldoonEdward A Neuwelt
May 19, 2011·Journal of Applied Toxicology : JAT·Luisa GiariAlessandro Martini
Nov 7, 2017·Journal of Applied Toxicology : JAT·Xiao KuangHongzhuo Liu
Jun 8, 2006·Neurochemical Research·Tufan HicdonmezSebahattin Cobanoglu
Feb 28, 2013·Metallomics : Integrated Biometal Science·Melani SooriyaarachchiJürgen Gailer

❮ Previous
Next ❯

Related Concepts

Related Feeds

Auditory Perception

Auditory perception is the ability to receive and interpret information attained by the ears. Here is the latest research on factors and underlying mechanisms that influence auditory perception.

Related Papers

Otology & Neurotology : Official Publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology
Won-Taek ChoeKay W Chang
© 2022 Meta ULC. All rights reserved