PMID: 8584414Nov 1, 1995Paper

Protection against hypoxic injury of rat proximal tubules by felodipine via a calcium-independent mechanism

Pflügers Archiv : European journal of physiology
S M PetersJ F Wetzels

Abstract

Most evidence for a key role of calcium entry in hypoxia-induced renal damage stems from studies with calcium channel blockers. In proximal tubules, a primary site of renal ischaemic injury, only phenyl-alkylamines, especially verapamil, have been studied. In the present study the effect of the dihydropyridine felodipine on hypoxic injury in isolated rat proximal tubules was investigated. To discriminate between the block of calcium entry and other effects, the enantiomers and a non-calcium blocking derivative of felodipine (H186/86) were included. Cell membrane injury was assessed by measuring the release of lactate dehydrogenase (LDH). At high concentrations (100 microM) felodipine, H186/86 and the two enantiomers all protected rat proximal tubules against hypoxia-induced injury to the same extent. Absence of extracellular calcium did not offer protection, but rather enhanced hypoxic injury. All dihydropyridines used increased the intracellular potassium concentration during normoxia. Felodipine attenuated the hypoxia-induced loss of cellular potassium. We have tried to mimic the effects of felodipine by using potassium channel blockers. The potassium channel blockers quinidine and glibenclamide afforded some protection again...Continue Reading

References

Jul 15, 1992·Proceedings of the National Academy of Sciences of the United States of America·K TsuchiyaP A Welling
May 1, 1992·The American Journal of Physiology·S D Hillyard, W Van Driessche
Jan 1, 1991·Journal of Cardiovascular Pharmacology·R W Schrier, T J Burke
Sep 30, 1991·Biochemical and Biophysical Research Communications·L J GaliettaG Romeo
Apr 1, 1990·Pflügers Archiv : European journal of physiology·M FriedrichH Hirche
Jan 1, 1990·Pflügers Archiv : European journal of physiology·M BleichR Greger
Dec 1, 1989·Biochemical Pharmacology·D R Janero, B Burghardt
Sep 1, 1988·The Journal of Membrane Biology·M M Hosey, M Lazdunski
Jul 1, 1994·The American Journal of Physiology·H MatsunagaP A Friedman
Aug 1, 1994·Cardiovascular Drugs and Therapy·R FerrariO Visioli
Dec 1, 1994·The Journal of Clinical Investigation·W B Reeves, S V Shah
May 1, 1994·The Journal of Clinical Investigation·A KribbenR W Schrier

❮ Previous
Next ❯

Citations

Mar 21, 1998·Kidney International·S M PetersR J Bindels
Nov 28, 2007·Annual Review of Pathology·Zheng DongManjeri A Venkatachalam
Sep 25, 1998·Life Sciences·S M PetersJ F Wetzels

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.