Protection against recurrent ocular herpes simplex virus type 1 disease after therapeutic vaccination of latently infected mice

Journal of Virology
C M RichardsN A Williams

Abstract

The potential of therapeutic vaccination of animals latently infected with herpes simplex virus type 1 (HSV-1) to enhance protective immunity to the virus and thereby reduce the incidence and severity of recurrent ocular disease was assessed in a mouse model. Mice latently infected with HSV-1 were vaccinated intranasally with a mixture of HSV-1 glycoproteins and recombinant Escherichia coli heat-labile enterotoxin B subunit (rEtxB) as an adjuvant. The systemic immune response induced was characterized by high levels of virus-specific immunoglobulin G1 (IgG1) in serum and very low levels of IgG2a. Mucosal immunity was demonstrated by high levels of IgA in eye and vaginal secretions. Proliferating T cells from lymph nodes of vaccinated animals produced higher levels of interleukin-10 (IL-10) than were produced by such cells from mock-vaccinated animals. This profile suggests that vaccination of latently infected mice modulates the Th1-dominated proinflammatory response usually induced upon infection. After reactivation of latent virus by UV irradiation, vaccinated mice showed reduced viral shedding in tears as well as a reduction in the incidence of recurrent herpetic corneal epithelial disease and stromal disease compared with m...Continue Reading

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Citations

May 14, 2004·Journal of Virology·E John Wherry, Rafi Ahmed
Jul 1, 2010·Toxins·Christelle BassetEvelyne Kohli
May 18, 2012·Clinical & Developmental Immunology·Patrick M Stuart, Tammie L Keadle
Jan 16, 2013·Clinical & Developmental Immunology·Aziz Alami Chentoufi, Lbachir Benmohamed
Jun 28, 2008·Seminars in Ophthalmology·Yoshitsugu Inoue
Feb 4, 2010·The Journal of Immunology : Official Journal of the American Association of Immunologists·Aziz A ChentoufiLbachir BenMohamed
Aug 10, 2020·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Zi-Hao LiuXin-Huan Wan

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