PMID: 8600763Mar 1, 1996Paper

Protection against Schistosoma mansoni and associated immune responses induced in the vervet monkey Cercopithecus aethiops by the irradiated cercaria vaccine

The American Journal of Tropical Medicine and Hygiene
Dorcas S YoleR A Wilson

Abstract

The efficacy of the radiation-attenuated schistosome vaccine in eliciting protective immunity was investigated in the vervet Cercopithecus aethiops. Three groups of test animals received one, three, or five exposures to 5,000-9,000 cercariae attenuated with 30 krad of gamma radiation from a 137Cs source, while a fourth group served as challenge controls. After a single vaccination, no statistically significant protection was found; after three vaccinations it reached its highest peak (48%) and five exposures resulted in reduced protection (39%). Examination of immunologic parameters supported these findings, with proliferative responses of peripheral blood lymphocytes being greatest in the group vaccinated three times. Specific immunoglobulin G (IgG) levels also peaked after three vaccinations, with clear evidence of a reduction after the fourth and fifth exposures. There was a clear correlation (r = 0.66) between the antibody level at the time of challenge and the protection observed in individual vervets. These data demonstrate that protective immunity to Schistosoma mansoni can be achieved with the attenuated vaccine in a highly susceptible nonhuman primate (i.e., 82% maturation of penetrant cercariae was recorded in challen...Continue Reading

Citations

Nov 5, 1997·The Pediatric Infectious Disease Journal·P J HotezJ Bethony
Mar 20, 2012·Parasitology·Angela van DiepenCornelis H Hokke
Feb 19, 2016·Parasites & Vectors·R Alan WilsonWilliam Castro-Borges
Aug 24, 2004·Infection and Immunity·Thomas M KariukiPatricia S Coulson
Jun 23, 2006·Infection and Immunity·Thomas M KariukiPatricia S Coulson
May 26, 2017·Veterinary Clinical Pathology·Elizabeth M ScallanRoberta M Palmour
Sep 22, 2018·Parasite Immunology·Moses EgesaStephen Cose
Dec 22, 2017·Emerging Topics in Life Sciences·R Alan WilsonWilliam Castro-Borges
Aug 23, 2003·Experimental Parasitology·A Kwame NyameRichard D Cummings

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