PMID: 6982472Sep 1, 1982Paper

Protection against syngeneic lymphoma by a long-lived cytotoxic T-cell clone

Proceedings of the National Academy of Sciences of the United States of America
M O DaileyI L Weissman

Abstract

The effect of a cloned T-cell line on the in vivo growth of syngeneic lymphoma cells was studied. 1E4 is an H-2-restricted cytotoxic T-cell clone that efficiently kills Abelson virus-induced lymphoma target cells (L1-2) at low effector/target ratios, as measured by in vitro cytotoxicity assays. In addition, it is long lived in vitro in the absence of stimulation and survives for more than 1 wk in vivo in the absence of exogenous antigen or growth factors. Mice injected intraperitoneally with lethal doses of L1-2 and then treated with 1E4 survived longer than animals treated with saline or with a control T-cell clone. Multiple weekly injections of effector cells, or a single injection in animals given a low dose of tumor cells, resulted in 50-80% long-term survivors. The observation that intravenous injection of killer cells was less effective than intraperitoneal treatment, coupled with the previous demonstration of markedly abnormal circulatory patterns for T-cell clones, suggests that those animals succumbing to progressively growing neoplasm die because the effector cells are unable to home into peripheral sites of tumor deposition. Thus, although this cytotoxic T-cell clone does have useful in vivo activity, its function ma...Continue Reading

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Citations

Jan 14, 1993·Journal of Immunological Methods·A Rudolphi, J Reimann
Dec 17, 1986·Biochimica Et Biophysica Acta·R A Robins
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Feb 8, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Christian H PoehleinBernard A Fox

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