Protection against tetanus toxin in mice nasally immunized with recombinant Lactococcus lactis expressing tetanus toxin fragment C

Vaccine
P M NortonR W Le Page

Abstract

Mice inoculated intranasally (i.n.) with a recombinant strain of live Lactococcus lactis expressing tetanus toxin fragment C (TTFC), produced both serum and secretory antibodies to TTFC. Killed bacteria which had accumulated TTFC intracellularly in vitro also elicited protective serum antibody responses. There was no requirement for either colonization or invasion of the mucosa. In addition secretory antibody responses in the lung and nasal tissues were elicited after i.n. inoculation in the presence of an adjuvant.

Citations

Dec 2, 2011·Annual Review of Food Science and Technology·Jerry Wells
Apr 13, 1999·Infectious Disease Clinics of North America·J D Gradon, L I Lutwick
Aug 23, 2001·Advanced Drug Delivery Reviews·N MielcarekC Locht
Aug 23, 2001·Advanced Drug Delivery Reviews·S S Davis
Jan 7, 2005·Applied Microbiology and Biotechnology·A R RahaH L Foo
Oct 26, 2011·Microbial Cell Factories·Luis G Bermúdez-HumaránPhilippe Langella
Jan 11, 2003·Biotechnology & Genetic Engineering Reviews·Walter MaglianiLuciano Polonelli
Apr 16, 2005·Current Opinion in Biotechnology·Catherine StantonDouwe Van Sinderen
Oct 25, 2007·Journal of Molecular Microbiology and Biotechnology·Luis G Bermúdez-HumaránPhilippe Langella
Nov 22, 2005·Expert Opinion on Drug Delivery·Lothar Steidler
Oct 22, 2005·Journal of Applied Microbiology·C A PerezD Mendoza
Oct 24, 2006·Annals of the New York Academy of Sciences·Lothar Steidler, Pieter Rottiers
Nov 4, 2006·Vaccine·Sandrine A L AudouyPeter W M Hermans
Apr 21, 2006·Journal of Microbiological Methods·Chi-Ming Wu, Tung-Ching Chung
Feb 5, 2015·Clinical and Experimental Vaccine Research·Shee Eun LeeJoon Haeng Rhee
Jul 24, 2004·Expert Review of Vaccines·Jong-Beak Park, Lance L Simpson
Apr 5, 2000·Ophthalmic Plastic and Reconstructive Surgery·J P FezzaW Dettbarn
Mar 18, 2008·Nature Reviews. Microbiology·Jerry M Wells, Annick Mercenier
May 8, 2016·Applied Microbiology and Biotechnology·Miao WangLi Pan
Jun 29, 2006·Microbiology·Peter Lee, Gaétan M Faubert
Sep 3, 2010·Clinical and Vaccine Immunology : CVI·Sangun LeeJohn E Herrmann
Apr 23, 2004·Infection and Immunity·Corinne GrangetteAnnick Mercenier
Nov 23, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Luis G Bermúdez-HumaránPhilippe Langella

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.