Protection by chlorophyllin and indole-3-carbinol against 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP)-induced DNA adducts and colonic aberrant crypts in the F344 rat

Carcinogenesis
D GuoR H Dashwood

Abstract

The most abundant heterocyclic amine in fried ground beef, 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP), induces colon carcinomas in the male F344 rat. The potential chemopreventive effects of two compounds, namely, the 'interceptor molecule' chlorophyllin (CHL) and a modulator of carcinogen activation, indole-3-carbinol (I3C), were examined in a PhIP colon carcinogenesis model. During weeks 3 and 4 of a 16-week study, F344 rats were given PhIP by oral gavage (50 mg/kg body weight, alternating days). Inhibitors were given either before and during PhIP exposure, after PhIP treatment, or continuously for 16 weeks. Treatment of rats with 0.1% CHL in the drinking water inhibited the formation of aberrant crypt foci (ACF) with > or = 4 crypts/focus, from 1.4 +/- 0.9 in controls to 0.7 +/- 0.3 following post-initiation CHL treatment, and to 0.3 +/- 0.5 in rats given CHL continuously for 16 weeks (mean +/- SD; P < 0.05). Potent inhibition of PhIP-induced ACF occurred following initiation, post-initiation and continuous exposure to 0.1% I3C in the diet. Using the initiation protocol, I3C completely inhibited the induction of the ACF with > or = 4 crypts/focus. In a separate experiment, rats were given 0.1% CHL in the drinking...Continue Reading

Citations

Jan 1, 1996·Journal of Cellular Biochemistry. Supplement
Mar 5, 2003·Teratogenesis, Carcinogenesis, and Mutagenesis·Yogeshwer ShuklaPankaj Taneja
May 5, 1998·Chemico-biological Interactions·R H Dashwood
May 12, 1997·Mutation Research·T Sugimura
Jun 9, 2001·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Z YuR H Dashwood
Jul 5, 2003·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·R H Dashwood, M Xu
Sep 9, 1999·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·A B RenwickB G Lake
Feb 14, 1998·Cancer Letters·S ChernomorskyR D Poretz
Jul 14, 1999·Toxicology Letters·R C Agrawal, S Kumar
Aug 8, 2001·Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP·S Katchamart, D E Williams
May 11, 2006·Photochemical & Photobiological Sciences : Official Journal of the European Photochemistry Association and the European Society for Photobiology·R B CopeN I Kerkvliet
Jan 31, 2006·The Proceedings of the Nutrition Society·Anthony LynnBrian Ratcliffe
Nov 16, 2007·Nutrition and Cancer·Misty R Saracino, Johanna W Lampe
Nov 16, 2007·Nutrition and Cancer·Richard D VerschoyleAndreas J Gescher
Apr 15, 1999·Proceedings of the Society for Experimental Biology and Medicine·R H DashwoodA Razzuk
May 2, 2001·European Journal of Cancer Prevention : the Official Journal of the European Cancer Prevention Organisation (ECP)·R H DashwoodD T Horio
Oct 20, 2015·The American Journal of Chinese Medicine·Lamia LahouarLotfi Achour
Dec 11, 2007·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Michael T SimonichGeorge S Bailey

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