Protection by metals against ethanol-induced gastric mucosal injury in the rat. Comparative biochemical and pharmacologic studies implicate protein sulfhydryls

Gastroenterology
D Dupuy, S Szabo

Abstract

Recent evidence suggests a role of endogenous sulfhydryls (SHs) in gastric "cytoprotection." Because divalent metals bind to or oxidize SH groups, their effect on ethanol-induced gastric erosions was studied. For comparative biochemical studies the SH cysteamine, the glutathione depletor diethylmaleate. and SH alkylating agent N-ethylmaleimide (NEM) were also used. Rats pretreated with CdCl2, ZnCl2, or Cu(NO3)2 6 h before absolute ethanol showed a significant dose-dependent decrease in the mucosal lesions. Copper was effective in preventing the lesions up to 15 min before the ethanol. Iron and manganese were active at 30 min, but not at 6 h before the ethanol lesions. Indomethacin administration decreased the protection afforded by iron, manganese, and cadmium, but did not modify that by lead and copper. N-ethylmaleimide abolished the protection by iron, manganese, and cadmium, but did not affect the protection caused by lead and copper when given after the metals. However, when NEM was given before lead and copper, it diminished the protection. Secretory studies revealed that cadmium and zinc slightly inhibited gastric acid secretion, but a similar reduction of acid output by cimetidine did not decrease the ethanol-induced gas...Continue Reading

Citations

Apr 8, 1999·Free Radical Research·A SamuniD Rachmilewitz
Sep 21, 2006·Journal of Gastroenterology and Hepatology·Ken-ichiro MikamiSumio Watanabe
Mar 1, 1987·Postgraduate Medicine·D B Wilson
Mar 1, 1989·Medical Toxicology and Adverse Drug Experience·S SzaboK D Rainsford
Oct 1, 1991·Scandinavian Journal of Gastroenterology·C LoguercioC Del Vecchio Blanco
Jun 1, 1992·The Journal of Pharmacy and Pharmacology·K D Rainsford, M W Whitehouse
Aug 1, 1988·Biological Trace Element Research·F BarbarinoI Marinescu
Oct 1, 1989·Scandinavian Journal of Gastroenterology·C A Gutiérrez-Cabano
May 1, 1988·Digestive Diseases and Sciences·G PihanS Szabo
Feb 1, 1995·The Journal of Pharmacy and Pharmacology·J V EspluguesJ Esplugues
Jul 12, 1995·Annals of the New York Academy of Sciences·G B Glavin, D D Smyth
Jul 1, 1991·Digestive Diseases and Sciences·K TakeuchiS Okabe
Jan 1, 1995·Biological Trace Element Research·G OnerU K Sentürk
May 5, 2000·Fundamental & Clinical Pharmacology·C BlandizziM Del Tacca
Mar 1, 1992·Journal of Inorganic Biochemistry·M AlberghinaE Rizzarelli
Mar 24, 2010·Toxicology and Applied Pharmacology·Andrea GerbinoMatilde Colella

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.