PMID: 1208616Sep 1, 1975Paper

Protection by nicotine from behavioral disruption caused by reticular formation stimulation in the rat

Pharmacology, Biochemistry, and Behavior
J M NelsenL Goldstein

Abstract

Male Sprague-Dawley rats prepared with chronic electrodes in the mesencephalic reticular formation were trained to perform on a visual attention task. Short trains of electric current delivered to the reticular formation effectively blocked performance in a reversible and reproducible fashion. Subcutaneous administration of 100 mug/kg nicotine (as the base) served to attenuate the behavioral disruption caused by reticular stimulation. The suggestion that it is a nicotine-induced limbic system activation which antagonizes the behavioral disruption caused by electrically-induced reticular over-activation, is discussed.

References

Dec 1, 1965·Electroencephalography and Clinical Neurophysiology·J Villablanca
Jun 29, 1973·Psychopharmacologia·I P StolermanM E Jarvik
Jan 1, 1968·Psychological Review·A Routtenberg
Aug 1, 1959·Electroencephalography and Clinical Neurophysiology·E GRASTYANH DONHOFFER
May 1, 1960·Electroencephalography and Clinical Neurophysiology·H L BATSEL
Nov 1, 1949·Electroencephalography and Clinical Neurophysiology·G Moruzzi, H W Magoun

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Citations

Jan 1, 1989·Psychoneuroendocrinology·O F Pomerleau, J Rosecrans
Oct 10, 2001·Hearing Research·A W Harkrider, C A Champlin

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