PMID: 11339622May 8, 2001Paper

Protection by selenium of lead-acetate-induced alterations on rat submandibular gland function

Human & Experimental Toxicology
M AbdollahiK Soltaninejad

Abstract

Pure submandibular saliva was collected intraorally by micro polyethylene cannulation of anaesthetized rats using pilocarpine as a secretagogue. Twenty-four days treatment with lead acetate 0.05% in drinking water altered salivary function. Except for flow rate that was (P<0.01) increased by lead acetate, the reminder of parameters, concentrations of total protein and calcium and the activity of N-acetyl-beta-D-glucosaminidase (NAG) in submandibular secretions were decreased significantly (P<0.01) by lead acetate. Selenium (2.5 mg l(-1)) in drinking water for 24 days did not induce any significant change in saliva secretory function. Pretreatment by selenium, prevented the lead acetate-induced decrease of NAG activity and concentrations of calcium and protein (P<0.01). The increased flow rate by lead acetate was also affected by selenium pretreatment and reached the level of control. It is concluded that selenium can protect rat submandibular gland function from lead-acetate-induced adverse effects. Properties of selenium as an antioxidant, free radical scavenger and maintenance of cell membrane integrity may be possible mechanisms of its protective effects.

References

Nov 1, 1976·Toxicology·S C RastogiK C Srivastava
Feb 15, 1991·Biochemical Pharmacology·J P Bressler, G W Goldstein
Jun 1, 1988·The Journal of Nutrition·S Vadhanavikit, H E Ganther
Feb 1, 1987·Journal of Dental Research·J D CastleR Cameron
Oct 15, 1970·The Japanese Journal of Physiology·R P Suddick, I L Shannon
Sep 1, 1983·Archives of Toxicology·E HabermannP Janicki
Jul 1, 1983·Acta Pharmacologica Et Toxicologica·S J FloraS K Tandon
Feb 1, 1983·Japanese Journal of Pharmacology·K NakagawaK Kuriyama
Oct 1, 1980·Toxicology and Applied Pharmacology·K NakagawaK Kuriyama
Dec 1, 1994·General Pharmacology·A R Dehpour, M Abdollahi
Feb 1, 1995·Tropical Animal Health and Production·K NachimuthuR A Venkatesan
May 1, 1994·Current Opinion in Nephrology and Hypertension·J A StaessenA Amery
Jul 1, 1997·Mechanisms of Ageing and Development·H Molina, M García
Feb 12, 1998·Industrial Health·S Acharya, U R Acharya
Jun 1, 1997·Biological Trace Element Research·B NehruA Iyer
Sep 15, 1998·Journal of Biochemical and Molecular Toxicology·A I Othman, M A El Missiry
Aug 27, 1999·Toxicology·V N Adonaylo, P I Oteiza
Aug 30, 2000·Lancet·M P Rayman
Jan 1, 1961·The Biochemical Journal·J BorooahP G Walker

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Citations

May 4, 2006·Journal of Physiology and Biochemistry·Om Ali Y El-Khawaga
Aug 28, 2012·Biological Trace Element Research·Aleksandra KasperczykSławomir Kasperczyk
Mar 22, 2013·Daru : Journal of Faculty of Pharmacy, Tehran University of Medical Sciences·Mehdi FarhoudiReza Rikhtegar
Dec 3, 2003·The Tohoku Journal of Experimental Medicine·Leyla KuntsalYigit Sirin
Nov 19, 2011·Drug and Chemical Toxicology·Pavle RandjelovicIvan Ilic
Dec 25, 2012·Toxicology and Applied Pharmacology·Mohammad Amin RezvanfarMohammad Abdollahi
Jan 1, 2007·Environmental Toxicology and Pharmacology·S Djekoun-BensoltaneC Thorin
Jan 21, 2011·Toxicology Mechanisms and Methods·Amir Ebrahim MiroliaeeMohammad Abdollahi
Mar 16, 2011·Toxicology Letters·Patrícia ReckziegelMarilise Escobar Bürger
Apr 8, 2010·Toxicology and Industrial Health·Ali Akbar MalekiradMohammad Abdollahi
Dec 23, 2003·Human & Experimental Toxicology·Mohammad AbdollahiArezou Bahreini-Moghadam
Jan 1, 2005·Toxicology Mechanisms and Methods·Pardeep Sidhu, Bimla Nehru

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