Protection effect of trigonelline on liver of rats with non-alcoholic fatty liver diseases

Asian Pacific Journal of Tropical Medicine
Dong-Fang ZhangRan Li

Abstract

To study the effect of trigonelline on the change of indicators of serum transaminase, lipoprotein and liver lipid of model rats with non-alcoholic fatty liver diseases and on the expression level of Bcl-2 and Bax proteins. A total of 45 SD rats were randomly divided into the control group, model group and trigonelline intervention group. Rats in the control group were fed with the common diet, while rats in the model group and intervention group were fed with the high fat diet. 8 weeks later, the intervention group received the intragastric administration of trigonellin e (with the dosage of 40 mg/kg/d) for 8 weeks; while control group and model group received the intragastric administration of saline with the equal dosage. Blood was taken from the abdominal aorta of rats 8 weeks later, detecting the level of a series of indicators of ALT, AST, TG, TC, HDL-C and LDL-C in the serum. After the rats were sacrificed, detect the indicators of TG, TC, SOD and MDA in the liver tissue of rats, as well as the expression of Bcl-2 and Bax in the liver tissue. Results of histopathologic examination showed that the damage degree of liver for rats in the trigonelline intervention group was smaller than the one in the model group, with signi...Continue Reading

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Citations

Mar 1, 2019·Molecular Medicine Reports·Feng LiuXiaolin Xu
Oct 6, 2020·Phytotherapy Research : PTR·Minji ChoiJong Won Yun
Oct 7, 2020·Journal of Ethnopharmacology·Lidiane Schultz BranquinhoCandida Aparecida Leite Kassuya

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