Protection effects of Taurine supplementation against cisplatin-induced nephrotoxicity in rats

Chemotherapy
Sherif Y Saad, Ammar C Al-Rikabi

Abstract

Taurine, which is the major intracellular free beta-amino acid, is known to be an antioxidant and a membrane-stabilizing agent. This study was designed to investigate the protective role of taurine supplementation against cisplatin-induced nephrotoxicity. Male Wistar rats were divided into six groups and treated as follows: (1) saline-treated control drinking tap water, (2) saline-treated plus taurine-supplemented (1.5% taurine in the drinking water), (3) saline-treated plus taurine-depleted (3% beta-alanine in the drinking water), (4) cisplatin-treated, CDDP 6 mg/kg intraperitoneally, (5) taurine-supplemented plus CDDP-treated and (6) taurine-depleted plus CDDP-treated. Rats were sacrificed 7 days after CDDP treatment, and serum as well as kidneys were isolated and analyzed. CDDP-treated rats showed increased kidney weight as a percentage of total body weight, serum creatinine and BUN levels and decreased serum albumin and calcium levels. Also, CDDP treatment resulted in a depletion of kidney GSH content, a reduction in the kidney glutathione peroxidase (GSH-Px) activity and increased kidney MDA production level. Taurine supplementation attenuated CDDP-induced nephrotoxicity which was manifested by jeopardizing the elevation i...Continue Reading

Citations

Jun 9, 2005·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·X Han, R W Chesney
Aug 6, 2013·Amino Acids·Mir Kaisar AhmadRiaz Mahmood
Jan 1, 2010·Indian Journal of Clinical Biochemistry : IJCB·S Noori, Tabassum Mahboob
Oct 15, 2003·Free Radical Biology & Medicine·Yuki ShinoRyozo Oishi
Jan 22, 2005·Clinical and Experimental Pharmacology & Physiology·Sherif Y SaadMouied Alashari
Mar 4, 2005·Clinical and Experimental Pharmacology & Physiology·Adel R A Abd-AllahOthman A Al-Shabanah
Feb 21, 2006·Clinical and Experimental Pharmacology & Physiology·Hanan H HagarMaha Arafa
Jan 25, 2008·Acta Pharmacologica Sinica·Md Abdul Hye KhanEdward James Johns
Aug 18, 2005·Mediators of Inflammation·Ricardo GonzálezEnis Rojas
Sep 7, 2004·Chemotherapy·Mohamed M Sayed-AhmedAbdel-Moneim M Osman
Jan 12, 2011·Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology·Hanne Sørup TastesenIan Henry Lambert
Sep 6, 2005·Biological & Pharmaceutical Bulletin·Yuka ShimedaKazuhiko Tanaka
May 9, 2009·Journal of the American Society of Nephrology : JASN·Xiaobin HanRussell W Chesney
Jan 1, 2012·ISRN Veterinary Science·Sae-Kwang KuJoo Wan Kim
Jun 9, 2006·Kidney International·M S MozaffariS W Schaffer
Sep 20, 2011·Experimental and Toxicologic Pathology : Official Journal of the Gesellschaft Für Toxikologische Pathologie·Karima Rjiba-TouatiHassen Bacha
Jul 27, 2011·Environmental Toxicology and Pharmacology·Sally S AlamAbeer H Abd El-Rahim
Jan 30, 2010·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Martins EkorEbenezer O Farombi
Jan 12, 2010·Experimental and Toxicologic Pathology : Official Journal of the Gesellschaft Für Toxikologische Pathologie·Yi AnXiaoxu Zhou
Dec 24, 2015·Canadian Journal of Physiology and Pharmacology·Khaled A AlhumaidhaHelmy Moawad
Apr 9, 2009·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Abir A SaadLamiaa K El-Shennawy
Sep 4, 2007·Experimental and Toxicologic Pathology : Official Journal of the Gesellschaft Für Toxikologische Pathologie·Md Abdul Hye KhanEdward James Johns
Jan 22, 2005·Fundamental & Clinical Pharmacology·Göksel SenerGül Ayanoğlu-Dülger
Jul 18, 2009·Chemistry : a European Journal·Marian Zajac, René Peters
Nov 2, 2007·Clinical and Experimental Pharmacology & Physiology·Abdulaziz M AleisaMohamed M Sayed-Ahmed
Mar 4, 2008·Basic & Clinical Pharmacology & Toxicology·Suhel ParvezSheikh Raisuddin
Mar 15, 2006·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Badreldin H Ali, Mansour S Al Moundhri
Mar 25, 2006·Clinica Chimica Acta; International Journal of Clinical Chemistry·Heena TabassumSuhel Parvez
Sep 15, 2006·BioFactors·Anurag KuhadKanwaljit Chopra
May 9, 2009·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·M I YousefL K El-Shennawy
Aug 21, 2007·Human & Experimental Toxicology·Heena TabassumSheikh Raisuddin

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