Protection from autoimmune diabetes by adjuvant therapy in the non-obese diabetic mouse: the role of interleukin-4 and interleukin-10

Immunology and Cell Biology
F CalcinaroK J Lafferty

Abstract

Insulin-dependent diabetes mellitus (IDDM) is an autoimmune disease that is characterized by the destruction of insulin-producing beta-cells in the pancreatic islets. A single administration of CFA prevents clinical hyperglycaemia in non-obese diabetic (NOD) mice. We have previously shown that CFA administration does not eliminate insulitis in the pancreas of the treated animals, but diverts the disease process from a destructive to a non-destructive pathway. We provide evidence that this phenomenon may be under cytokine control. Neutralizing monoclonal antibodies against IL-4 and IL-10 were injected, singularly or in combination, into CFA-treated NOD mice. Antibody treatment did not lead to the development of overt diabetes; however, a marked impairment of glucose tolerance was shown in about one half of the mice treated with a combination of the two antibodies at the end of the study. This functional abnormality correlated with the histological loss of pancreatic islet tissue. These studies suggest a role for IL-4 and IL-10 in CFA-induced protection from diabetes in the NOD mouse. They also suggest that, in this animal model, the nature of the autoimmune response to islet tissue (either destructive or non-destructive) may ref...Continue Reading

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Citations

Sep 20, 2002·The New England Journal of Medicine·Jean-Francois Bach
Mar 13, 2001·Annual Review of Immunology·J F Bach, L Chatenoud
Aug 14, 2009·American Journal of Physiology. Renal Physiology·Hye Ryoun JangHamid Rabb
Mar 20, 2010·PloS One·Sean P Stromberg, Jean M Carlson
Sep 29, 2005·Expert Opinion on Biological Therapy·Lucienne Chatenoud, Jean-François Bach
Nov 1, 2003·Annals of the New York Academy of Sciences·Jean-François Bach
Dec 28, 2002·Journal of Neuroscience Research·Yuval TalFelix Mor
May 4, 2001·Journal of Autoimmunity·J F Bach
May 25, 2016·Journal of Autoimmunity·Chantal KuhnLucienne Chatenoud
Jun 24, 2004·Cardiovascular Pathology : the Official Journal of the Society for Cardiovascular Pathology·Jacob GeorgeArie Roth
Aug 18, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·A BotM von Herrath

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