Protection from Mycobacterium avium complex disease in human immunodeficiency virus-infected persons with a history of tuberculosis

The Journal of Infectious Diseases
C R HorsburghS E Thompson

Abstract

Risk of Mycobacterium avium complex disease was examined in human immunodeficiency virus (HIV)-infected patients with and without a history of tuberculosis. Information was obtained by retrospective review of charts of patients in HIV clinics in 10 US cities. Among 1363 patients with <200 CD4 cells/mm3 seen at Grady Memorial Hospital (GMH), 11 (17%) of 66 with a history of a positive purified protein derivative (PPD) skin test acquired M. avium infection, while 29 (16%) of 185 who were PPD-negative (but not anergic) did not (P = .85). Only 4 (8%) of 49 GMH patients with a history of tuberculosis acquired M. avium infection compared with 252 (19%) of 1314 GMH patients without a history of tuberculosis (P = .05). Proportional hazards analysis of risk factors for M. avium infection among 441 persons with and 8702 persons without a history of tuberculosis in 9 other cities confirmed protection from M. avium infection in persons with a history of tuberculosis (relative risk, 0.52; 95% confidence interval, 0.36-0.76; P < .001). Prior tuberculosis provides protection against M. avium infection in HIV-infected persons, possibly by stimulation of antimycobacterial immunity.

Citations

Oct 26, 2000·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·D P O'BrienV L Krause
Apr 26, 2003·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Francisco-Javier San-AndrésAngel del Palacio
Feb 9, 2012·American Journal of Respiratory and Critical Care Medicine·Jennifer AdjemianD Rebecca Prevots
Jul 9, 2002·The Journal of Infection·C F von ReynA N A Tosteson
Nov 30, 1998·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·S D Shafran
Jan 6, 2001·Memórias do Instituto Oswaldo Cruz·P H LagrangeJ L Herrmann
May 6, 2006·American Journal of Epidemiology·Carrie ReedC Robert Horsburgh
Jan 18, 2020·Antibiotics·Clara M BentoTânia Silva
Mar 7, 2019·Frontiers in Immunology·Getahun AbateDaniel F Hoft
Aug 6, 2020·Curēus·Ryan F AmidonPaul Kaloostian
Jun 30, 2000·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·M E Wilson

❮ Previous
Next ❯

Related Concepts

Related Feeds