PMID: 3773504Oct 1, 1986Paper

Protection from venous air embolism with fluorocarbon emulsion FC-43

The Journal of Surgical Research
B D SpiessA D Ivankovich

Abstract

Intraoperative venous air embolism (VAE) occurs frequently in some surgical settings and may cause devastating hemodynamic consequences. Perfluorocarbon emulsions have been investigated as artificial oxygen carrying medias. They also have the properties of enhanced nitrogen solubility and a small particle size. FC-43 (Oxypherol, Alpha Therapeutic Corp., Los Angeles, California) was compared to three other volume expanders in 91 New Zealand White laboratory rabbits exposed to continuous VAE. The animals were anesthetized and ventilated by one of four modalities. They then received one of the volume expanders at 20 cc/kg over 30 min. After a 10-min stabilization period, a constant femoral venous air infusion (0.25 cc/kg/min) was begun and continued until death. Time until death, total volume of air infused, femoral arterial pressure, central venous pressure, and ECG (Lead II) were recorded. Death was defined as the cessation of pulsatile blood pressure. Arterial and central venous gases were analyzed pre and post volume expansion and at intervals of every 5 min after the beginning of the femoral air infusion. Results showed a significant prolongation of life for the animals receiving FC-43 at 10 and 20 cc/kg as a volume expander ...Continue Reading

References

Jun 1, 1979·Anesthesiology·G A GronertJ D Michenfelder
May 26, 1969·JAMA : the Journal of the American Medical Association·J D MichenfelderK Rehder
Nov 1, 1966·Anesthesiology·E S Munson, H C Merrick
Dec 1, 1981·The Annals of Thoracic Surgery·R M EngelmanW A Dobbs

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Citations

Apr 25, 2003·Medical Hypotheses·Donald E Watenpaugh
Apr 28, 2005·Clinical and Experimental Pharmacology & Physiology·David J DooletteAllison M Martinez
Jun 11, 2008·The Journal of Surgical Research·Bruce D SpiessKevin R Ward
May 22, 2010·Journal of Veterinary Emergency and Critical Care·Nicole PacificoReid K Nakamura
May 1, 1997·The Annals of Thoracic Surgery·R P CochranB D Spiess
Nov 1, 1986·Stroke; a Journal of Cerebral Circulation·B D SpiessA D Ivankovich
Oct 24, 2006·Anesthesia and Analgesia·Kenji YoshitaniG Burkhard Mackensen
Jan 2, 2007·Anesthesiology·Marek A MirskiThomas J K Toung
Jan 1, 1992·Biomaterials, Artificial Cells, and Immobilization Biotechnology : Official Journal of the International Society for Artificial Cells and Immobilization Biotechnology·R M Winslow
Jul 15, 2006·Journal of Applied Physiology·Richard E Moon
Feb 7, 2003·Journal of Applied Physiology·David M Eckmann, Vladimir N Lomivorotov
Nov 7, 2019·European Journal of Applied Physiology·Dirk Mayer, Katja Bettina Ferenz
Jul 1, 2021·The Journal of Surgical Research·Jiepei ZhuBruce D Spiess

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