PMID: 20132735Feb 6, 2010Paper

Protection of burn-induced skin injuries by the flavonoid kaempferol

BMB Reports
Byoung Kwon ParkHyung-Joo Kwon

Abstract

Thermal burn injury induces inflammatory cell infiltrates in the dermis and thickening of the epidermis. Following a burn injury, various mediators, including reactive oxygen species (ROS), are produced in macrophages and neutrophils, exposing all tissues to oxidative injury. The anti-oxidant activities of flavonoids have been widely exploited to scavenge ROS. In this study, we observed that several flavonoids-kaempferol, quercetin, fisetin, and chrysin-inhibit LPS-induced IL-8 promoter activation in RAW 264.7 cells. In contrast with quercetin and fisetin, pretreatment of kaempferol and chrysin did not decrease cell viability. Inflammatory cell infiltrates in the dermis and thickening of the epidermis induced by burn injuries in mice was relieved by kaempferol treatment. However, the injury was worsened by fisetin, quercetin, and chrysin. Expression of TNF-a induced by burn injuries was decreased by kaempferol. These findings suggest the potential use of kaempferol as a therapeutic in thermal burn-induced skin injuries. [BMB reports 2010; 43(1): 46-51].

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Citations

Mar 22, 2012·Journal of Biomedical Science·Yung Hyun Choi, Hye Young Park
Dec 16, 2011·Lipids in Health and Disease·Hossam EbaidAli Metwalli
May 31, 2011·Immunobiology·Ming-Kuem LinChing-Liang Chu
Jun 28, 2013·Journal of the European Academy of Dermatology and Venereology : JEADV·W ChenJ Ring
Aug 14, 2015·BMC Complementary and Alternative Medicine·Ana Cristina Justino JácomoGláucia Maria Tech dos Santos
Sep 15, 2012·Chemical & Pharmaceutical Bulletin·Yun ChaoPao-Chu Wu
Oct 20, 2019·Journal of Ethnopharmacology·Fabiana de Freitas FigueiredoDomingos Tabajara de Oliveira Martins

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