PMID: 2484724Oct 23, 1989Paper

Protection of CA1 pyramidal cell function by MK-801 following ischaemia in the gerbil

Neuroscience Letters
R Gill, J A Kemp

Abstract

Electrophysiological recordings were made from hippocampal slices of gerbils which had undergone a 5 min period of bilateral carotid occlusion. Normal CA1 population spikes, field potentials and synaptic responses were obtained from slices of gerbils pretreated with the N-methyl-D-aspartate antagonist, MK-801 (10 mg/kg, i.p., 1 h before the occlusion). In contrast, no CA1 population spike could be obtained from slices of untreated gerbils, although field potentials and population spikes were obtained from the dentate granule cell region of these slices in response to perforant path stimulation. These studies indicate that the CA1 pyramidal cells identified histologically as protected by MK-801 from selective neuronal degeneration produced by a 5 min period of global ischaemia, are also functionally protected and retain their normal synaptic responsiveness.

References

Apr 7, 1978·Brain Research·P AndersenH Wigström
Feb 1, 1986·Annals of Neurology·S M Rothman, J W Olney
Sep 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·E H WongL L Iversen

❮ Previous
Next ❯

Citations

Mar 24, 1995·European Journal of Pharmacology·F AlaouiJ M Stutzmann
Dec 17, 1991·Brain Research. Developmental Brain Research·J A GorterM A Corner
Jan 1, 1991·Neuroscience·R Schmidt-Kastner, T F Freund
Apr 29, 1998·Progress in Neurobiology·D Corbett, S Nurse
Jul 1, 1991·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·M A WarnerB J Crain
Nov 15, 2013·The Korean Journal of Physiology & Pharmacology : Official Journal of the Korean Physiological Society and the Korean Society of Pharmacology·Young-Na HurBoe-Gwun Chun

❮ Previous
Next ❯

Related Concepts

Related Feeds

Brain Ischemia

Brain ischemia is a condition in which there is insufficient blood flow to the brain to meet metabolic demand. Discover the latest research on brain ischemia here.