Protection of chlorophyllin against oxidative damage by inducing HO-1 and NQO1 expression mediated by PI3K/Akt and Nrf2

Free Radical Research
Yanlin ZhangJin-yuan Zhao

Abstract

Green vegetables are thought to have a chemoprotective effect on the basis of epidemiologic evidence. This study investigated whether chlorophyllin (CHL) could induce antioxidant enzymes and confer protection against oxidative damage. The results showed that CHL could induce HO-1 and NQO1 expression in human umbilical vein endothelial cell (HUVEC) in a time- and dose-dependent manner and protect them against hydrogen peroxide caused oxidative damage. The induction of HO-1 and NQO1 by CHL was accompanied with the accumulation of transcription factor Nrf2 in nucleus and the activation of PI3K/Akt signalling pathway. Additionally, the specific inhibitor of PI3K/Akt could obviously decrease not only the induced expression of HO-1 and NQO1 but also the antioxidant effect of CHL. In conclusion, this study proved that CHL exerts antioxidant effect by inducing HO-1 and NQO1 expression mediated by PI3K/Akt and Nrf2. One thinks CHL may have promise to be prophylactic pharmaceuticals without adverse effects.

References

Jan 1, 1992·Toxicology and Applied Pharmacology·T J MonksD G Graham
Jan 1, 1987·Free Radical Biology & Medicine·G R Buettner
Aug 6, 2000·Free Radical Biology & Medicine·K HensleyR A Floyd
Oct 6, 2000·Biochimica Et Biophysica Acta·J P KamatT P Devasagayam
Oct 18, 2000·Free Radical Biology & Medicine·A K Jaiswal
Nov 29, 2001·Proceedings of the National Academy of Sciences of the United States of America·P A EgnerT W Kensler
Jul 20, 2002·Blood·Viktória JeneyGyörgy Balla
Jul 19, 2003·Pharmacological Reviews·Frank A D T G WagenerCarl G Figdor
Mar 25, 2004·Neurochemical Research·Franca EspositoFiliberto Cimino
Mar 30, 2004·Methods in Enzymology·Jed W FaheyPaul Talalay
Apr 28, 2004·Biochimica Et Biophysica Acta·S Santosh KumarKrishna B Sainis
Apr 28, 2004·Free Radical Biology & Medicine·Anil K Jaiswal
May 12, 2004·Current Medicinal Chemistry·G PoliE Chiarpotto
Jul 17, 2004·Free Radical Biology & Medicine·Truyen NguyenCecil B Pickett
Aug 1, 1950·American Journal of Surgery·C R LAM, B E BRUSH
Nov 24, 2004·Drug Metabolism Reviews·David Ross
Jan 5, 2005·Free Radical Biology & Medicine·Hye-Youn ChoSteven R Kleeberger
May 26, 2005·Cancer Letters·Jeong-Sang Lee, Young-Joon Surh
Sep 30, 2005·Toxicological Sciences : an Official Journal of the Society of Toxicology·Susan C TiltonDavid E Williams
Nov 15, 2005·Circulation Research·Hongjun LiuToren Finkel
Jan 10, 2006·International Immunopharmacology·Cheol-Heui YunSeung Hyun Han
Apr 8, 2006·Physiological Reviews·Stefan W RyterAugustine M K Choi
Apr 18, 2006·Molecular Immunology·Deepak SharmaKrishna B Sainis
Feb 10, 2007·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·John P Fruehauf, Frank L Meyskens
Jun 20, 2007·Free Radical Research·Yanlin ZhangJinyuan Zhao
Oct 25, 2007·Antioxidants & Redox Signaling·Akos PuticsCsaba Soti

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Citations

Oct 12, 2010·Journal of Lipid Research·Taras AfonyushkinValery N Bochkov
Aug 15, 2008·Medical Hypotheses·Kai-Shan TaoKe-Feng Dou
Aug 21, 2010·Journal of Food Science·Keiko SuzukiHiroshi Ishihara
Feb 5, 2015·Nutrition and Cancer·Siddavaram NaginiAdayapalam T Natarajan
Jun 15, 2016·Nanoscale Research Letters·Bin SongLongQuan Shao
Aug 16, 2016·Molecular Nutrition & Food Research·Si Qin, De-Xing Hou
Jun 24, 2016·Beilstein Journal of Nanotechnology·Bin SongLongquan Shao
Jul 31, 2018·Oxidative Medicine and Cellular Longevity·Kateřina VaňkováLibor Vítek
Dec 26, 2018·Human & Experimental Toxicology·H M HafezN M Zenhom
Jul 3, 2021·Free Radical Biology & Medicine·Kyung-Soo ChunYoung-Joon Surh
Jul 3, 2021·Macromolecular Bioscience·Carlotta PucciGianni Ciofani

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