Protection of Cochlear Ribbon Synapses and Prevention of Hidden Hearing Loss.

Neural Plasticity
Mei WeiPeng Lin

Abstract

In the auditory system, ribbon synapses are vesicle-associated structures located between inner hair cells (IHCs) and spiral ganglion neurons that are implicated in the modulation of trafficking and fusion of synaptic vesicles at the presynaptic terminals. Synapse loss may result in hearing loss and difficulties with understanding speech in a noisy environment. This phenomenon happens without permanent hearing loss; that is, the cochlear synaptopathy is "hidden." Recent studies have reported that synapse loss might be critical in the pathogenesis of hidden hearing loss. A better understanding of the molecular mechanisms of the formation, structure, regeneration, and protection of ribbon synapses will assist in the design of potential therapeutic strategies. In this review, we describe and summarize the following aspects of ribbon synapses: (1) functional and structural features, (2) potential mechanisms of damage, (3) therapeutic research on protecting the synapses, and (4) the role of synaptic regeneration in auditory neuropathy and the current options for synapse rehabilitation.

References

Jun 22, 2000·Proceedings of the National Academy of Sciences of the United States of America·M DuanB Canlon
Sep 8, 2001·Journal of the Association for Research in Otolaryngology : JARO·M YagiY Raphael
Jan 22, 2002·Nature Neuroscience·Elisabeth Glowatzki, Paul A Fuchs
Mar 6, 2003·Brain Research·Yoshimitsu OhinataJochen Schacht
Sep 11, 2003·Current Opinion in Neurobiology·Paul A FuchsTobias Moser
Apr 23, 2005·The Journal of Physiology·Paul Albert Fuchs
Nov 26, 2005·Acta Oto-laryngologica·M HultcrantzA E Stenberg
Dec 16, 2005·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Andreas BrandtTobias Moser
Feb 1, 2006·Ear and Hearing·Donald HendersonBo Hua Hu
Mar 7, 2006·Postgraduate Medical Journal·A Howarth, G R Shone
Jun 10, 2006·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·Rosamaria SantarelliEdoardo Arslan
Jul 26, 2006·Cell and Tissue Research·T M Boeckers
Jun 11, 2008·Journal of Neuroscience Research·Masahiro MatsumotoJuichi Ito
Nov 14, 2008·The Journal of Biological Chemistry·Neeliyath A RamakrishnanDennis G Drescher
May 23, 2009·Journal of Human Genetics·Jihane RomanosRegina Célia Mingroni-Netto
Jun 12, 2009·Journal of Neurophysiology·Zhiqiang ChenWilliam F Sewell
Aug 4, 2009·Nature Neuroscience·Laura Taylor AltoMark H Tuszynski
Aug 28, 2009·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Didier DulonChristine Petit
Nov 13, 2009·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Sharon G Kujawa, M Charles Liberman
May 28, 2010·Nature·Akiko TerauchiHisashi Umemori
Oct 6, 2010·The Journal of Cell Biology·Colin P Johnson, Edwin R Chapman
Nov 4, 2010·Nature Reviews. Neuroscience·Gary Matthews, Paul Fuchs
Jun 7, 2011·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Shen Kiat LimYoon Pin Lim
Jul 26, 2011·Nature Neuroscience·Josefin SnellmanDavid Zenisek
Apr 12, 2012·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Shui-bing LiuMing-gao Zhao
Sep 11, 2012·Trends in Neurosciences·Tina PangršičTobias Moser
Oct 10, 2012·The Anatomical Record : Advances in Integrative Anatomy and Evolutionary Biology·Jochen SchachtLeonard P Rybak
Dec 1, 2012·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Lavinia SheetsTeresa Nicolson
Dec 21, 2012·Nature Reviews. Neuroscience·Hyungju Park, Mu-ming Poo
Feb 21, 2013·Journal of the Association for Research in Otolaryngology : JARO·Mingjie TongAlbert S B Edge
Mar 29, 2013·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Stéphane F MaisonM Charles Liberman
Oct 12, 2013·Journal of the Association for Research in Otolaryngology : JARO·Yasheng YuanAlbert S B Edge
Mar 7, 2014·Frontiers in Systems Neuroscience·Hari M BharadwajBarbara G Shinn-Cunningham

❮ Previous
Next ❯

Methods Mentioned

BETA
ubiquitination

Related Concepts

Related Feeds

Auditory Perception

Auditory perception is the ability to receive and interpret information attained by the ears. Here is the latest research on factors and underlying mechanisms that influence auditory perception.