Protection of cortex by overlying meninges tissue during dynamic indentation of the adolescent brain

Acta Biomaterialia
David B MacManusMichael D Gilchrist

Abstract

Traumatic brain injury (TBI) has become a recent focus of biomedical research with a growing international effort targeting material characterization of brain tissue and simulations of trauma using computer models of the head and brain to try to elucidate the mechanisms and pathogenesis of TBI. The meninges, a collagenous protective tri-layer, which encloses the entire brain and spinal cord has been largely overlooked in these material characterization studies. This has resulted in a lack of accurate constitutive data for the cranial meninges, particularly under dynamic conditions such as those experienced during head impacts. The work presented here addresses this lack of data by providing for the first time, in situ large deformation material properties of the porcine dura-arachnoid mater composite under dynamic indentation. It is demonstrated that this tissue is substantially stiffer (shear modulus, μ=19.10±8.55kPa) and relaxes at a slower rate (τ1=0.034±0.008s, τ2=0.336±0.077s) than the underlying brain tissue (μ=6.97±2.26kPa, τ1=0.021±0.007s, τ2=0.199±0.036s), reducing the magnitudes of stress by 250% and 65% for strains that arise during indentation-type deformations in adolescent brains. We present the first mechanical a...Continue Reading

References

Feb 24, 2016·Scientific Reports·David B MacManusMichael D Gilchrist

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Citations

Sep 29, 2020·Frontiers in Bioengineering and Biotechnology·Baptiste PierratAisling Ní Annaidh
Nov 17, 2020·Journal of Neurotrauma·Darragh R WalshJohn J E Mulvihill
Dec 12, 2020·Scientific Reports·Darragh R WalshJohn J E Mulvihill
Jul 28, 2021·Acta Biomaterialia·Darragh R WalshJohn J E Mulvihill
Oct 26, 2021·Frontiers in Bioengineering and Biotechnology·Andrea MenichettiNele Famaey

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Brain Injury & Trauma

brain injury after impact to the head is due to both immediate mechanical effects and delayed responses of neural tissues.