Protection of cortical neurons from excitotoxicity by conjugated linoleic acid

Journal of Neurochemistry
Waylon T HuntChristopher M Anderson

Abstract

Conjugated linoleic acid (CLA) is an isomeric mixture of 18-carbon polyunsaturated fatty acids with conjugated double bonds derived from linoleic acid. CLA is sourced nutritionally from dairy products and ruminant animal meat and is associated with beneficial heath effects in several disorders, including cancer, atherosclerosis, diabetes, obesity, and inflammation. We investigated the potential for CLA to protect neurons from death in stroke simulated by exposing cultured mouse embryonic cortical neurons to glutamate. CLA (10 30 μM) significantly protected neuronal survival in response to glutamate (3 μM) excitotoxicity when given concurrently with glutamate. CLA (30 μM) also reduced neuron death when given up to 5 h after glutamate exposure (73.1 ± 13.3% protection, p < 0.01), suggesting potential utility as a post-injury therapeutic tool. The cis-9, trans-11 CLA isomer, which comprises about 40% of the commercial CLA mixture used, was identified as the active neuroprotective species. The other major species, trans-10, cis-12 CLA (40%) was without significant neuroprotective effect. CLA significantly increased neuronal Bcl-2 levels when given with glutamate and attenuated glutamate-induced dissipation of mitochondrial membrane...Continue Reading

References

Jan 1, 1984·Journal of Neurochemistry·F Fonnum
Oct 29, 1993·Science·J T Coyle, P Puttfarcken
Sep 15, 1993·Biochemical and Biophysical Research Communications·P MontpiedS M Paul
Jan 1, 1996·Annual Review of Cell and Developmental Biology·T LembergerW Wahli
Feb 12, 1998·The American Journal of Clinical Nutrition·B K HerbelT D Shultz
Oct 28, 1999·The Journal of Nutrition·A Brodie
Oct 28, 1999·The Journal of Nutrition·S Y Moya-Camarena, M A Belury
Mar 11, 2003·Reproduction, Nutrition, Development·Jean-Charles Martin, Karine Valeille
Mar 20, 2003·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Nam E Joo, Chung S Park
Apr 11, 2003·Neuroscience Letters·Tomonori NakanishiMitsuhiro Furuse
Jun 6, 2003·Biochemical and Biophysical Research Communications·Koji NagaoTeruyoshi Yanagita
Aug 2, 2005·Biochimica Et Biophysica Acta·Mauro FaSebastiano Banni
Nov 3, 2005·Advances in Food and Nutrition Research·Donald L PalmquistDale E Bauman
May 3, 2006·The Journal of Nutritional Biochemistry·Arunabh BhattacharyaGabriel Fernandes
Jun 14, 2006·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Yi ZhaoJuraj Culman
Oct 21, 2006·Journal of Neural Transmission·P Riederer, S Hoyer
Nov 23, 2006·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Borja García-BuenoJuan C Leza
Nov 6, 2007·Frontiers in Bioscience : a Journal and Virtual Library·Ramya KapadiaRaghu Vemuganti
Nov 22, 2007·Expert Opinion on Therapeutic Targets·Juan C CoronaRicardo Tapia
Feb 19, 2008·Archives of Medical Research·Ana María Estrada SánchezLourdes Massieu
May 6, 2008·Brain Research·Angela M SikorskiRodney A Swain
Oct 14, 2009·Current Opinion in Cell Biology·Dirk Brenner, Tak W Mak
Dec 29, 2009·Frontiers in Bioscience (Elite Edition)·Maria A NavarroJose Martinez-Gonzalez

❮ Previous
Next ❯

Citations

Dec 19, 2012·Biochimica Et Biophysica Acta·Eunyoung LeeYoungjoo Kwon
May 17, 2013·Nutritional Neuroscience·Juliana Kessia Barbosa SoaresMaria do Carmo Medeiros
Jul 24, 2013·Evidence-based Child Health : a Cochrane Review Journal·Esther CorenAnne J Martin
May 25, 2021·Frontiers in Molecular Biosciences·Rekha TripathiRobert Fredriksson

❮ Previous
Next ❯

Related Concepts

Related Feeds

Anthelmintics

Anthelmintics or antihelminthics are a group of antiparasitic drugs that expel parasitic worms (helminths) and other internal parasites from the body by either stunning or killing them and without causing significant damage to the host. Discover the latest research on anthelmintics here.