Protection of Critical Structures During Radiofrequency Ablation of Adjacent Myocardial Tissue Using Catheter Tips Partially Insulated With Thermally Conductive Material

JACC. Clinical Electrophysiology
Duy T NguyenWilliam H Sauer

Abstract

This study sought to determine whether partially insulated focused ablation (PIFA) catheters can minimize risk of injury to critical structures, such as the phrenic nerve and atrioventricular (AV) node, during ablation of adjacent myocardial tissue. PIFA catheters using thermally conductive materials may have differential radiofrequency (RF) heating properties allowing for tailored RF application with more precision. Open-irrigated, 4- and 8-mm RF ablation catheter tips were insulated partially by coating one-half of their surfaces with a layer of vinyl, silicone, vinyl-silicone, polyurethane, or a composite of aluminum oxide/boron nitride (AOBN). These coated catheters or corresponding noninsulated catheters were positioned with 10 g of force on viable bovine myocardial tissue during RF application in an ex vivo setup. Tip temperatures, power, and lesion volumes were compared. The most effective coating, AOBN, was modified further by adding fenestrations to aid in passive cooling. PIFA catheters with fenestrated AOBN coating were then tested in an in vivo porcine model to target myocardial tissue adjacent to the AV node and the phrenic nerve. PIFA catheters all demonstrated higher tip temperatures, although silicone- and AOBN-...Continue Reading

Citations

Jan 4, 2019·Journal of Cardiovascular Electrophysiology·Duy T NguyenWilliam H Sauer

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