Protection of dentate hilar cells from prolonged stimulation by intracellular calcium chelation

Science
H E Scharfman, P A Schwartzkroin

Abstract

Prolonged afferent stimulation of the rat dentate gyrus in vivo leads to degeneration only of those cells that lack immunoreactivity for the calcium binding proteins parvalbumin and calbindin. In order to test the hypothesis that calcium binding proteins protect against the effects of prolonged stimulation, intracellular recordings were made in hippocampal slices from cells that lack immunoreactivity for calcium binding proteins. Calcium binding protein-negative cells showed electrophysiological signs of deterioration during prolonged stimulation; cells containing calcium binding protein did not. When neurons without calcium binding proteins were impaled with microelectrodes containing the calcium chelator BAPTA, and BAPTA was allowed to diffuse into the cells, these cells showed no deterioration. These results indicate that, in a complex tissue of the central nervous system, an activity-induced increase in intracellular calcium can trigger processes leading to cell deterioration, and that increasing the calcium binding capacity of a cell decreases its vulnerability to damage.

References

Nov 9, 1979·Science·F A SchanneJ L Farber
Nov 17, 1978·Brain Research·P A Schwartzkroin, L H Mathers
Dec 15, 1978·The Journal of Comparative Neurology·D G Amaral
Jun 1, 1988·Trends in Neurosciences·R T Richardson, M R DeLong
Oct 1, 1988·Trends in Neurosciences·M P Blaustein
Feb 1, 1984·Journal of Neurophysiology·R A Fricke, D A Prince
Sep 28, 1981·Life Sciences·J L Farber

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Citations

Aug 1, 1994·Hippocampus·P S Buckmaster, P A Schwartzkroin
Feb 1, 1993·Cell and Tissue Research·C AndressenM R Celio
Dec 1, 1993·Pflügers Archiv : European journal of physiology·W Jarolimek, U Misgeld
Jan 1, 1990·Anatomy and Embryology·R NitschM Frotscher
Jan 1, 1997·Experimental Brain Research·T VerinaB Ghetti
May 21, 2011·Brain Structure & Function·Lutz SlomiankaDavid P Wolfer
Mar 29, 2011·Journal of Neural Transmission·Johannes AttemsMathias Heikenwalder
Mar 16, 1993·European Journal of Pharmacology·J M BoeynaemsJ C Braekman
Jan 1, 1996·Life Sciences·J SatrústeguiA Martínez-Serrano
Sep 1, 1990·Trends in Pharmacological Sciences·B Meldrum, J Garthwaite
Jul 1, 1992·Trends in Neurosciences·C W Heizmann, K Braun
Aug 1, 1992·Trends in Neurosciences·K G BaimbridgeJ H Rogers
Jan 1, 1994·Archives of Gerontology and Geriatrics·D R Thal, W Schlote
May 1, 1992·Progress in Neuro-psychopharmacology & Biological Psychiatry·M Akil, D A Lewis
Jan 1, 1991·Progress in Neurobiology·E W LothmanJ L Stringer
Aug 17, 1992·Neuroscience Letters·B W StrowbridgeP A Schwartzkroin
Feb 19, 1993·Neuroscience Letters·J M Dubinsky

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