PMID: 9188561Jul 1, 1997Paper

Protection of human immunodeficiency virus type 2-exposed seronegative macaques from mucosal simian immunodeficiency virus transmission

Journal of Virology
P PutkonenR Thorstensson

Abstract

At present it is not known which form of immunity would be most effective against infection with human immunodeficiency virus (HIV). To evaluate the possible role of cellular immunity, we examined whether four HIV type 2-exposed but seronegative macaques developed cellular immune responses and determined whether these exposed macaques were resistant to mucosal transmission of simian immunodeficiency virus (SIV). Following intrarectal challenge with SIV, 2 monkeys were protected against detectable SIV replication and another showed suppressed viral replication compared to 14 persistently infected controls. The two protected monkeys demonstrated SIV-specific cytotoxic T lymphocytes before as well as after SIV challenge. Here we provide evidence that activation of the cell-mediated arm of the immune system only, without antibody formation, can control SIV replication in macaques. The results imply that vaccines that stimulate a strong and broad cellular immune response could prevent mucosal HIV transmission.

References

Oct 3, 1991·Nature·E J Stott
Mar 1, 1991·AIDS Research and Human Retroviruses·P PutkonenG Biberfeld
Aug 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·R C DesrosiersM D Daniel
Jan 1, 1995·Nature Medicine·S Rowland-JonesT Corrah
May 28, 1993·Science·J SalkG M Shearer
Jul 20, 1996·AIDS Research and Human Retroviruses·M Quesada-RolanderP Putkonen
Aug 10, 1996·AIDS Research and Human Retroviruses·L WaltherR Thorstensson

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Citations

Apr 20, 2002·Current Opinion in Infectious Diseases·L M Lee, D K Henderson
Oct 25, 2002·AIDS Research and Human Retroviruses·Barbara L ShacklettPreston A Marx
Jul 9, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Luwy MuseyM Juliana McElrath
Apr 6, 2004·Journal of Medical Primatology·Johan SöderlundPeter Biberfeld
Apr 20, 2001·Nature·A J McMichael, S L Rowland-Jones
Jun 21, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·A Ross LopesMala K Maini
Mar 9, 2006·Current HIV/AIDS Reports·Barbara L Shacklett
Jan 15, 2002·AIDS Research and Human Retroviruses·M J BurkhardE A Hoover
Oct 29, 2000·AIDS Research and Human Retroviruses·J MillsN Almond
Sep 2, 1998·Current Opinion in Immunology·R P Johnson, R C Desrosiers

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