PMID: 11605996Oct 19, 2001Paper

Protection of IB-MECA against myocardial stunning in conscious rabbits is not mediated by the A1 adenosine receptor

Basic Research in Cardiology
Eitaro KodaniJohn A Auchampach

Abstract

The goal of this study was to determine whether the protective effects of the A3AR agonist N6-(3-iodobenzyl)adenosine-5'-N-methylcarboxamide (IB-MECA) against myocardial stunning are mediated by the A1AR. Six groups of conscious rabbits underwent a sequence of six 4-minute coronary occlusion (O)/4-minute reperfusion (R) cycles for three consecutive days (days 1, 2, and 3). In vehicle-treated rabbits (group I), the recovery of systolic wall thickening (WTh) in the ischemic/reperfused region was markedly depressed on day 1, indicating the presence of severe myocardial stunning. On days 2 and 3, however, the recovery of systolic WTh was markedly accelerated, indicating the presence of late ischemic preconditioning (PC). When rabbits were pretreated with the A1AR agonist 2-chloro-N6-cyclopentyladenosine (CCPA, 100 microg/kg i.v.) or with IB-MECA (100 microg/kg i.v.) 10 min prior to the first sequence of O/R cycles on day 1 (group III and V, respectively), the recovery of systolic WTh was markedly accelerated compared to vehicle-treated animals (reflected as an approximately 48% decrease in the total deficit of systolic WTh). The magnitude of the protection afforded by adenosine receptor agonists was equivalent to that provided by l...Continue Reading

Citations

Mar 17, 2005·Cardiovascular Drugs and Therapy·Yukihiro YoshimuraRobert D Lasley
Mar 18, 2005·Journal of Medicinal Chemistry·Susanna TchilibonKenneth A Jacobson
Dec 20, 2003·American Journal of Physiology. Heart and Circulatory Physiology·Xian-Liang TangRoberto Bolli
Jan 12, 2007·Cardiovascular Drug Reviews·Zhelong XuEdward A Norfleet
Nov 23, 2005·Life Sciences·Amanda J ZattaJohn P Headrick
Dec 26, 2008·Current Opinion in Pharmacology·Dwaine S Burley, Gary F Baxter
Jul 24, 2004·American Journal of Physiology. Heart and Circulatory Physiology·Gentian KristoRobert D Lasley
Apr 12, 2003·American Journal of Physiology. Heart and Circulatory Physiology·John A AuchampachGarrett J Gross
Oct 17, 2003·American Journal of Physiology. Heart and Circulatory Physiology·John P HeadrickKevin J Ashton
Jun 14, 2002·American Journal of Physiology. Heart and Circulatory Physiology·Mitsuhiro KudoMuhammad Ashraf
Oct 18, 2002·American Journal of Physiology. Heart and Circulatory Physiology·Eitaro KodaniRoberto Bolli
Jan 18, 2003·American Journal of Physiology. Heart and Circulatory Physiology·Xian-Liang TangRoberto Bolli

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