Protection of immunosuppressed mice against infection with pseudomonas aeruginosa by monoclonal antibodies to outer membrane protein OprI

Infection
R RahnerB U von Specht

Abstract

Two monoclonal antibodies (mAbs) designated 2A1 and 6A4 which had been shown to be directed against Pseudomonas aeruginosa outer membrane lipoprotein I were tested in cyclophosphamide treated mice for their protective ability against P. aeruginosa infection. Pretreatment of mice with either 2 mg of 2A1 or 4 mg of 6A4 in combination with lethally irradiated human leucocytes reduced the mortality after subsequent subcutaneous injection of 100 living P. aeruginosa organisms to 50% of the controls. Without leucocytes only mAb 2A1 (isotype IgG2b) showed protection (47%). Irradiated leucocytes alone without mAb did not protect the mice significantly from fatal P. aeruginosa infection.

References

Mar 31, 1977·The New England Journal of Medicine·J B AlaviR A Cooper
Nov 1, 1976·Infection and Immunity·L HarvathH J Amirault
Apr 1, 1985·European Journal of Clinical Microbiology·R E HancockE C Mouat
Dec 1, 1986·The Journal of Antimicrobial Chemotherapy·R E Hancock
Feb 1, 1973·The Journal of Surgical Research·C E JonesM Fisher
Dec 1, 1982·The Journal of Infectious Diseases·L M MuthariaR E Hancock
Aug 1, 1982·Proceedings of the National Academy of Sciences of the United States of America·D Herlyn, H Koprowski
Nov 1, 1983·Reviews of Infectious Diseases·B R Tegtmeier, B R Andersen
Nov 1, 1982·Reviews of Infectious Diseases·H MasurW T Stubenbord

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