PMID: 7083267Mar 1, 1982Paper

Protection of ischaemic myocardium with coenzyme Q10

Cardiovascular Research
Y NakamuraK Hara

Abstract

Protection of the ischaemic myocardium with Coenzyme Q10 (COQ10) following constriction of left anterior descending coronary artery was studied in 38 open-chest mongrel dogs. Left anterior descending coronary artery blood flow was independently reduced by tightening a constrictor around the vessel. Aortic pressure and left ventricular pressure were measured, and the Tension Time Index (TTI) was calculated. Myocardial segment shortening in the ischaemic area was measured with an ultrasonic dimension gauge. After obtaining haemodynamic data, the ischaemic myocardium was biopsied and the tissue sample was frozen in liquid nitrogen for adenosine triphosphate (ATP) analysis. Animals premedicated with COQ10 (20 mg . kg-1 iv) had a significantly higher ATP content in ischaemic myocardium (3.25 +/- 0.35 mumol . g-1 wet weight) compared with that in ischaemic myocardium of control animals (2.96 +/- 0.19) (P less than 0.05), when coronary blood flow was reduced by 50 to 74%. There were failure of ATP preservation by COQ10 with a further reduction in coronary blood flow. Changes in the pattern of myocardial segment shortening in the ischemic area induced by a 50 to 74% coronary blood flow reduction were less in COQ10 treated animals than ...Continue Reading

Citations

Jul 1, 1990·Journal of Clinical Pharmacology·S Greenberg, W H Frishman
May 1, 1989·Basic Research in Cardiology·H G ZimmerG Marschner
Apr 1, 1985·Journal of the American College of Cardiology·W H GaaschO H Bing
Dec 1, 1987·The Journal of Clinical Investigation·J L ZweierM L Weisfeldt
Oct 19, 2001·Japanese Heart Journal·N MuradP J Tucci
Jan 28, 2014·Pharmacology & Therapeutics·Karina HuynhRebecca H Ritchie
Jul 7, 2001·American Journal of Therapeutics·R J Gaytan, L M Prisant
Mar 1, 1986·Basic Research in Cardiology·B TörökZ Pollák

Related Concepts

Coenzyme Q10, ion (1-), (all-E)-isomer
Adenosine Triphosphate, Chromium Ammonium Salt
Coenzymes
Coronary Circulation
Coronary Heart Disease
Canis familiaris
Hemodynamics
Myocardial Contraction
Myocardium
Ubiquinone

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