Protection of mice from allergen-induced asthma by selenite: prevention of eosinophil infiltration by inhibition of NF-kappa B activation

The Journal of Biological Chemistry
Dae-Won JeongIck Young Kim

Abstract

The potential anti-inflammatory effect of sodium selenite in a mouse model of asthma was investigated. Selenite was injected into the peritoneum of allergen (ovalbumin)-sensitized mice before allergen challenge. Ovalbumin challenge resulted in activation of the transcription factor NF-kappaB and an increase in the expression of cell adhesion molecules (intercellular adhesion molecule 1, vascular cell adhesion molecule 1, and E-selectin, which are encoded by NF-kappaB-dependent genes) in lung tissue as well as in the recruitment of eosinophils to lung airways. These effects of ovalbumin challenge were all inhibited by pretreatment of mice with selenite. Selenite administration also increased the activity of selenium-dependent glutathione peroxidase in lung tissue. Furthermore, supplementation of A549 human airway epithelial cell cultures with selenite increased glutathione peroxidase activity as well as inhibited both the generation of hydrogen peroxide and the activation of NF-kappaB induced by tumor necrosis factor alpha in these cells. Selenite also reversed in vitro the activation of NF-kappaB induced by this cytokine in intact A549 cells. These results suggest that selenite regulates the activity of NF-kappaB by increasing ...Continue Reading

References

Aug 15, 1991·Archives of Biochemistry and Biophysics·F IslamO Hayaishi
Mar 1, 1989·Journal of Biochemistry·Y TashimaF Marumo
Dec 1, 1986·Current Eye Research·P L Bergad, W B Rathbun
Jun 1, 1983·European Journal of Biochemistry·O EppA Wendel
May 9, 1995·Proceedings of the National Academy of Sciences of the United States of America·M L HandelR L Sutherland
Jun 11, 1996·Proceedings of the National Academy of Sciences of the United States of America·V N GladyshevT C Stadtman
Jan 1, 1996·Archives of Toxicology·V MakropoulosK Schulze-Osthoff
Feb 1, 1997·Thorax·A SoutarK Brown
Mar 1, 1997·Biochimica Et Biophysica Acta·S R StapletonR F Kletzien
Jul 18, 1997·The Journal of Biological Chemistry·S PalludD L St Germain
Dec 16, 1997·Proceedings of the National Academy of Sciences of the United States of America·I Y Kim, T C Stadtman
Nov 10, 1998·The Journal of Nutrition·C Ip
Jan 16, 1999·Free Radical Biology & Medicine·M S StewartB C Pence
Jul 16, 1999·Journal of the American Dietetic Association·D H Holben, A M Smith
Jul 27, 1999·Current Opinion in Chemical Biology·A J Lewis, A M Manning
Sep 30, 1999·American Journal of Respiratory Cell and Molecular Biology·E HamelmannE W Gelfand
Oct 19, 1999·The Journal of Clinical Investigation·J A EliasR J Homer
Jan 5, 2000·American Journal of Respiratory and Critical Care Medicine·L HartK F Chung
Mar 18, 2000·The Journal of Biological Chemistry·H S ParkE J Choi
May 16, 2000·Chest·J W ChristmanT S Blackwell
Jul 27, 2000·Cancer Chemotherapy and Pharmacology·P B Caffrey, G D Frenkel
Nov 4, 2000·Respiratory Medicine·J C Baker, J G Ayres
Feb 13, 2001·The Journal of Clinical Investigation·Y Yamamoto, R B Gaynor
Feb 24, 2001·American Journal of Respiratory and Critical Care Medicine·A KanehiroE W Gelfand
Mar 27, 2001·Immunology and Cell Biology·D C WebbP S Foster
Apr 21, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·A TomkinsonE W Gelfand

❮ Previous
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Citations

Oct 26, 2006·Nature Reviews. Immunology·Graham Devereux
Jul 21, 2007·Nutrition and Cancer·Merrill J ChristensenBrett R Barzee
Oct 4, 2008·Microbial Ecology in Health and Disease·Anna HaugGraham H Lyons
Nov 23, 2006·Antioxidants & Redox Signaling·Hitoshi UenoKatsuhiko Nakamuro
Feb 7, 2012·Antioxidants & Redox Signaling·Anne M FitzpatrickLou Ann S Brown
Apr 1, 2009·Current Opinion in Clinical Nutrition and Metabolic Care·William Manzanares, Gil Hardy
Nov 25, 2003·American Journal of Respiratory and Critical Care Medicine·Rachel N RubinPatricia A Cassano
Jul 9, 2005·American Journal of Respiratory and Critical Care Medicine·Mark A BirrellMaria G Belvisi
Apr 18, 2013·American Journal of Respiratory Cell and Molecular Biology·Carla M SevinR Stokes Peebles
Apr 27, 2012·Critical Care : the Official Journal of the Critical Care Forum·William ManzanaresDaren K Heyland
Jun 26, 2013·AAPS PharmSciTech·Susanne R YoungrenMahavir B Chougule
Jan 18, 2006·Treatments in Respiratory Medicine·Melpo Christofidou-Solomidou, Vladimir R Muzykantov
Apr 11, 2014·Critical Care : the Official Journal of the Critical Care Forum·Yasser SakrKonrad Reinhart
Aug 15, 2014·Biochimica Et Biophysica Acta·Zhichao ZhangJianru Xiao
Dec 10, 2009·Experimental Lung Research·James R ShellerTimothy S Blackwell
Jun 22, 2007·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·G DevereuxA Seaton
Dec 9, 2009·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·K AllanG Devereux
Apr 29, 2009·Journal of Trace Elements in Medicine and Biology : Organ of the Society for Minerals and Trace Elements (GMS)·Matthias GründlingChristian Lehmann
Aug 30, 2008·Annals of Clinical Biochemistry·Afaf M Hassan
Mar 6, 2008·Journal of Trace Elements in Medicine and Biology : Organ of the Society for Minerals and Trace Elements (GMS)·Hitoshi UenoKatsuhiko Nakamuro
Mar 3, 2017·Immunity, Inflammation and Disease·Nour BaïzUNKNOWN EDEN Mother‐Child Cohort Study Group
Dec 20, 2014·Nutrition in Clinical Practice : Official Publication of the American Society for Parenteral and Enteral Nutrition·William ManzanaresDaren K Heyland
Feb 7, 2012·Nutrition in Clinical Practice : Official Publication of the American Society for Parenteral and Enteral Nutrition·Gil HardyWilliam Manzanares
Mar 10, 2017·International Journal of Food Sciences and Nutrition·Alie de BoerAalt Bast
Jun 10, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Chang-Hoon WooJae-Hong Kim
Oct 30, 2016·Critical Care : the Official Journal of the Critical Care Forum·William ManzanaresDaren K Heyland
Feb 15, 2017·Biological Trace Element Research·Xiaodan HuangYing Chang
May 29, 2014·Cancer Prevention Research·Keiichiro HiramotoMasayuki Yamamoto
Aug 2, 2003·Biochemical and Biophysical Research Communications·Sung-Jo KimSeongman Kang
Aug 23, 2005·Toxicology Letters·Youn Wook ChungIck Young Kim
Feb 2, 2011·Biochimica Et Biophysica Acta·Niki L Reynaert

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