Protection of mitochondrial function during ischemia by potassium cardioplegia: correlation with ischemic contracture

Circulation
J D SinkA S Wechsler

Abstract

The effect of potassium cardioplegia on mitochondrial function was evaluated in the ischemic isolated rat heart. Mitochondrial function as well as adenosine triphosphate (ATP) levels were determined at the initiation of ischemic contracture, at the completion of ischemic contracture, and 20 minutes following contracture completion. Group I received no cardioplegia prior to ischemia, while Group II received potassium cardioplegia prior to the onset of ischemia. The respiratory control index (RCI), which is the primary measure of the intactness of mitochondrial function, was calculated with both a NAD (nicotinamide adenine dinucleotide)-linked substrate and a FAD (flavin adenine dinucleotide)-linked substrate. Potassium cardioplegia significantly delayed ischemic contracture initiation and completion. Although the RCI and ATP levels decreased significantly at successive levels of contracture, there was no difference in the RCI or ATP content between Group I and Group II at contracture initiation or completion. Unlike previous investigations that have used a time-base to examine mitochondrial function and acute cardiac ischemic injury, we correlated mitochondrial function with the measurable physiologic event ischemic contracture....Continue Reading

Citations

Oct 1, 1980·The Annals of Thoracic Surgery·P R VouhéC M Grondin
Jan 1, 1982·Annals of the New York Academy of Sciences·R J MyerburgA L Bassett
Dec 30, 2008·PloS One·Yeong-Hoon ChoiFrancis X McGowan
Apr 1, 1984·The Annals of Thoracic Surgery·B M FreedmanA S Wechsler
Mar 1, 1992·Circulation·S W Ely, R M Berne
Jul 11, 2018·IEEE Transactions on Bio-medical Engineering·Ashish SingalPaul A Iaizzo
Mar 30, 2018·Annals of Biomedical Engineering·Ashish SingalPaul A Iaizzo

Related Concepts

Striadyne
Metazoa
Coronary Heart Disease
Use-Effectiveness
Flavitan
Heart Arrest, Induced
Mitochondria, Heart
NADH
Oxygen Consumption
Potassium

Related Feeds

Cardiology Journals

Discover the latest cardiology research in this collection of the top cardiology journals.