PMID: 3011713May 1, 1986

Protection of mouse jejunal crypt cells by WR-2721 after small doses of radiation

International Journal of Radiation Oncology, Biology, Physics
E L TravisI Kiss

Abstract

The ability of WR-2721 to protect jejunal crypt cells after single doses and multifractionated doses of radiation was studied. Effective dose survival curves for jejunal crypt cells were constructed over the dose range of 230 to 1600 cGy. WR-2721 was given 30 minutes before each fraction, in a regimen consisting of 200 mg/kg before the first radiation fraction, followed at 3 hr intervals by 100 mg/kg for a total of 12 drug doses for the largest number of fractions. Fractionation protocols were designed with common dose fractions in regimens with different fraction numbers, allowing a test of the hypothesis of equal effect per fraction and an estimate of the initial number of clonogens per crypt in both the drug treated and non-drug treated mice. The hypothesis of equal effect per fraction could not be rejected in either the drug or non-drug treated mice. An average number of 137 clonogens per crypt was estimated for the non-drug treated mice and 81 clonogens per crypt in the drug treated mice; the difference between these two values was not significant. The protection factor decreased with decreasing dose ranging from a high of 1.47 (95% C.L. = 1.44 to 1.50) after a single dose of 2000 cGy to a low of 1.21 (95% C.L. = 1.08 to 1...Continue Reading

References

Sep 1, 1974·Cancer·H R Withers, Kathy A Mason
Sep 1, 1984·International Journal of Radiation Oncology, Biology, Physics·M L MeistrichL Milas
Jun 1, 1984·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·A RojasJ Denekamp
Jun 1, 1964·The British Journal of Radiology·M C PIKE, T ALPER

Citations

Jan 1, 1989·Advances in Space Research : the Official Journal of the Committee on Space Research (COSPAR)·E J AinsworthR J Fry
Feb 15, 2005·International Journal of Radiation Oncology, Biology, Physics·David R CassattMichael P McCarthy
Dec 21, 2000·International Journal of Radiation Oncology, Biology, Physics·J C RoeskeA J Mundt
Aug 1, 1988·International Journal of Radiation Oncology, Biology, Physics·E L TravisI Basic
Dec 17, 2014·Seminars in Oncology·Deborah E Citrin, James B Mitchell
Jun 30, 2011·Free Radical Biology & Medicine·E L TravisMichael L Freeman
Mar 1, 1994·International Journal of Radiation Oncology, Biology, Physics·H ItoL Milas
May 1, 1989·International Journal of Radiation Oncology, Biology, Physics·F A Stewart
Jun 12, 2010·Journal of Experimental & Clinical Cancer Research : CR·Konstantinos H KatsanosEpameinondas V Tsianos

Related Concepts

Cell Survival
Dose-Response Relationship, Drug
Dose-Response Relationship, Radiation
Ethyol
Structure of Intestinal Gland
Mathematics
Mice, Inbred C3H
Organothiophosphorus Compounds
Gray Units
Whole-Body Irradiation

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