PMID: 11334073May 4, 2001Paper

Protection of pigs against challenge with virulent Streptococcus suis serotype 2 strains by a muramidase-released protein and extracellular factor vaccine

The Veterinary Record
Henk J WisselinkH E Smith

Abstract

The efficacy of a muramidase-released protein (MRP) and extracellular factor (EF) vaccine in preventing infection and disease in pigs challenged either with a homologous or a heterologous Streptococcus suis serotype 2 strain (MRP+EF+) was compared with the efficacy of a vaccine containing formalin-killed bacterin of S. suis serotype 2 (MRP+EF+). The enhancement of the immune response by different adjuvants (a water-in-oil emulsion [WO] and an aluminium hydroxide-based adjuvant [AH]) and their side effects were also studied. The MRP and EF were purified by affinity chromatography. Pigs were vaccinated twice at three weeks and six weeks of age and challenged intravenously with virulent S. suis serotype 2 strains (MRP+EF+) at eight weeks of age. At challenge, the pigs vaccinated with MRP+EF/WO had high anti-MRP and anti-EF titres and were protected as effectively as pigs vaccinated with WO-formulated vaccines with bacterin. Eight of the nine pigs survived the challenge and almost no clinical signs of disease were observed. The titres obtained with the MRP+EF/AH vaccine were low and only two of the five pigs were protected. Pigs vaccinated with either MRP or EF were less well protected; three of the four pigs died after challenge b...Continue Reading

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Citations

Jun 30, 2009·Animal Health Research Reviews·Christoph Georg Baums, Peter Valentin-Weigand
Aug 27, 2010·Clinical and Vaccine Immunology : CVI·Christoph Georg BaumsPeter Valentin-Weigand
Apr 19, 2011·Nihon saikingaku zasshi. Japanese journal of bacteriology·Daisuke Takamatsu
Oct 16, 2015·Expert Review of Vaccines·Mariela Segura
Apr 21, 2012·Veterinary Immunology and Immunopathology·Nadine BüttnerChristoph Georg Baums
Oct 2, 2004·Journal of Veterinary Medicine. B, Infectious Diseases and Veterinary Public Health·L BengaP Valentin-Weigand
Mar 29, 2008·FEMS Immunology and Medical Microbiology·Zongfu WuChengping Lu
Jun 6, 2009·FEMS Microbiology Letters·Miriam EsgleasMarcelo Gottschalk
Jun 10, 2016·BMC Microbiology·Astrid de GreeffHilde E Smith
Mar 22, 2016·PloS One·Edoardo ZaccariaPeter van Baarlen
Jun 15, 2007·Clinical and Vaccine Immunology : CVI·Yuanyi LiJosee Harel
Dec 26, 2008·Clinical and Vaccine Immunology : CVI·Christoph Georg BaumsPeter Valentin-Weigand
Apr 9, 2005·Clinical and Diagnostic Laboratory Immunology·Ogi Okwumabua, Sharmila Chinnapapakkagari
Mar 14, 2019·Frontiers in Cellular and Infection Microbiology·Fei ZhaoJianhua Wang
Jul 18, 2008·Journal of Proteome Research·Hongran GengYongqiang Jiang

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