PMID: 7032807Feb 1, 1982Paper

Protection of prostacyclin-like activity in human plasma-a non-enzymatic mechanism?

Clinical Science
D P MikhailidisP Dandona

Abstract

1. The rate of decay of the platelet antiaggregatory activity of prostacyclin in plasma and buffer solutions was investigated. 2. Platelet anti-aggregatory activity of prostacyclin was more stable in plasma than in buffer solutions at physiological pH. 3. The rate of decay of this activity increased with an increase in incubation temperature. 4. Preheating of plasma at 65 degrees C led to a marked but not total loss of its ability to "protect" prostacyclin. 5. Incubation of 6-keto prostaglandin F 1 alpha in plasma did not result in the appearance of platelet anti-aggregatory activity; nor did the decay curves of prostacyclin activity indicate the emergence of any new platelet anti-aggregatory activity. 6. Incubation of 6-keto-prostaglandin E1 in plasma did not lead to any loss of its platelet anti-aggregatory activity for prolonged periods. 7. We conclude that the marked prolongation of platelet anti-aggregatory activity of prostacyclin in plasma is not due to its enzymatic conversion into 6-keto-prostaglandin E1 but due to 'protection' of prostacyclin itself. This 'protection' is probably due to an interaction with a plasma protein.

Citations

Sep 1, 1982·British Journal of Clinical Pharmacology·M A BarradasP Dandona
Aug 8, 2006·Journal of Cardiovascular Pharmacology and Therapeutics·I Anita Jagroop, Dimitri P Mikhailidis
Dec 1, 1985·European Journal of Clinical Investigation·D P MikhailidisP Dandona
Jan 1, 1984·British Journal of Clinical Pharmacology·D P MikhailidisP Dandona
Oct 1, 1983·British Journal of Pharmacology·R J Griffiths, P K Moore
Jul 1, 1982·Annals of Clinical Biochemistry·D P MikhailidisP Dandona
Jan 1, 1983·Biochemical Pharmacology·K V HonnB F Sloane
Oct 1, 1983·Prostaglandins·P K Moore, R J Griffiths
Dec 1, 1985·Prostaglandins·A C PappK K Wu
Mar 1, 1988·Prostaglandins, Leukotrienes, and Essential Fatty Acids·D P MikhailidisP Dandona

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