Protection of rabbits against experimental pasteurellosis by a streptomycin-dependent Pasteurella multocida serotype 3:A live mutant vaccine.

Infection and Immunity
Y S Lu, S P Pakes

Abstract

Pasteurella multocida (serotype 3:A) was isolated from a rabbit with clinical signs of suppurative rhinitis. This P. multocida strain was mutagenized with N-methyl-N'-nitro-N-nitrosoguanidine to obtain a genetically stable streptomycin-dependent mutant, from which a life vaccine was prepared. Pasteurella-free rabbits were inoculated intranasally three times at weekly intervals and challenged intranasally with a virulent serotype 3:A rabbit P. multocida isolate 2 weeks after the third vaccination. The rabbits were killed 2 to 3 weeks later. The vaccine did not cause clinical disease, death, or gross or microscopic lesions. Furthermore, the vaccine protected the challenge rabbits from developing clinical disease, death, and gross lesions. However, mild focal lung lesions were noted in several of the vaccinated-challenged animals. In contrast, nonvaccinated-challenged rabbits developed pyrexia and anorexia. Furthermore, three of four of these rabbits died with severe gross lesions including pyothorax, suppurative pericarditis, and fibrinopurulent pneumonia. Microscopically, the four nonvaccinated rabbits had moderate to severe suppurative pneumonia and mild to moderate suppurative rhinitis, and two had mild tympanitis. The mutant ...Continue Reading

References

Sep 1, 1978·The Journal of Physiology·M J Kluger, L K Vaughn
Apr 12, 1975·The Veterinary Record·G R Carter, S W Rundell
Feb 1, 1967·The Journal of Infectious Diseases·M Reitman
Oct 1, 1974·Proceedings of the National Academy of Sciences of the United States of America·H GreenbergR M Chanock
Jan 1, 1972·The Journal of Infectious Diseases·H L DuPontE J Gangarosa
Mar 1, 1972·Applied Microbiology·O FelsenfeldR B Brannon

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Citations

Sep 27, 2013·BioMed Research International·Somia A NassarSoad M Nasr
Jan 1, 1992·Veterinary Research Communications·F I Ifeanyi, W E Bailie
Jul 31, 1998·Vaccine·R Verma, T N Jaiswal

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