PMID: 11917280Mar 28, 2002Paper

Protection of salivary function by intensity-modulated radiation therapy in patients with head and neck cancer

Seminars in Radiation Oncology
K S Clifford Chao

Abstract

The degree of xerostomia has been reported to depend on the radiation dose and the salivary gland volume irradiated. Sparing salivary function can be achieved by reducing radiation dose to the salivary glands or using a radiation protector, such as amifostine (Ethyol). In this report, the author reviews clinical experiences in intensity-modulated radiation therapy (IMRT) for head and neck cancer. In experiences, the dosimetric advantage of IMRT did translate into significant reduction of late salivary toxicity in patients with oropharyngeal carcinoma. The author has found no adverse impact on tumor control and disease-free survival in patients treated with IMRT. Further, when studying the dose response of parotid gland after irradiation, it was found that the stimulated saliva flow 6 months after IMRT treatment reduced at approximately 4% per Gy exponentially of the mean parotid dose. The authors also review existing clinical data on the combination of amifostine and radiation and the potential therapeutic gain in combining IMRT with amifostine.

Citations

Feb 19, 2005·Current Oncology Reports·Mark S ChambersRandal S Weber
Sep 4, 2008·Current Oncology Reports·Jeffrey J MeyerChristopher G Willett
Sep 20, 2006·Technology in Cancer Research & Treatment·James S WelshMinesh P Mehta
Jun 27, 2007·Journal of Applied Clinical Medical Physics·Robert TakamiyaPing Xia
Jun 25, 2005·Japanese Journal of Clinical Oncology·Yasumasa NishimuraMinoru Suzuki
Jul 8, 2020·Journal of the National Comprehensive Cancer Network : JNCCN·David G PfisterSusan D Darlow
Aug 29, 2009·Strahlentherapie und Onkologie : Organ der Deutschen Röntgengesellschaft ... [et al]·Anna DelanaValentina Vanoni
Jan 16, 2008·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Mary P WalkerBrian Wichman
Dec 31, 2003·Current Treatment Options in Oncology·Gokhan OzyigitK S Clifford Chao
Sep 27, 2012·ACS Applied Materials & Interfaces·Shruti Nambiar, John T W Yeow
Jun 1, 2010·Journal of Medical Imaging and Radiation Sciences·William Tyler Tran, Carol Gillies

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