Protection of sensory function in diabetic rats by Neotrofin

European Journal of Pharmacology
Nigel A CalcuttAndrew P Mizisin

Abstract

We investigated the ability of Neotrofin, an agent that enhances endogenous nerve growth factor (NGF) levels, to prevent phenotypic, functional and structural changes that occur in the peripheral nerve of streptozotocin-diabetic rats. Eight weeks of Neotrofin treatment prevented depletion of NGF protein in plantar foot skin and sciatic nerve of diabetic rats and increased NGF protein in associated skeletal muscles. These effects were accompanied by maintenance of normal nerve levels of the neuropeptides substance P and calcitonin gene related peptide. Thermal hypoalgesia and conduction slowing of large sensory fibres in diabetic rats were ameliorated by Neotrofin treatment, whereas there was no effect on conduction slowing in large motor fibres or on reduced myelinated fibre axonal calibre. Enhancing endogenous production of neurotrophic factors using small molecules may be an alternative to either exogenous treatment with neurotrophic factors or gene therapy as a therapeutic approach to treating diabetic neuropathy.

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Citations

Oct 1, 2009·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Thierry Bordet, Rebecca M Pruss
Mar 10, 2009·Pakistan Journal of Biological Sciences : PJBS·H R SameniM Makvandi
Dec 3, 2008·Expert Opinion on Emerging Drugs·Gordon S Lynch
Apr 23, 2011·European Journal of Pharmacology·Xiu-Ying YangGuan-Hua Du
May 4, 2007·Experimental Neurology·Igor VareniukIrina G Obrosova
Apr 2, 2014·Diabetes/metabolism Research and Reviews·Roman StavniichukMark A Yorek
May 27, 2010·Diabetes/metabolism Research and Reviews·Eric P DavidsonMark A Yorek
Mar 12, 2008·The Journal of Pain : Official Journal of the American Pain Society·Kazuhiro SugimotoMinoru Yasujima
Aug 21, 2010·The American Journal of Pathology·Irina G ObrosovaRobert E Schmidt
May 1, 2009·Nature Reviews. Drug Discovery·Nigel A CalcuttAnn Marie Schmidt
Sep 15, 2018·International Journal of Impotence Research·Bai-Bing YangYu-Tian Dai

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