PMID: 2891214Sep 1, 1987

Protection of sheep against footrot with a recombinant DNA-based fimbrial vaccine

Veterinary Microbiology
J R EgertonJ S Mattick


Recombinant Pseudomonas aeruginosa cells containing the Bacteroides nodosus fimbrial subunit gene under the transcriptional control of a strong promoter produce large amounts of B. nodosus-type fimbriae. We have carried out vaccination trials which show that these fimbriae are just as effective as either natural fimbriae or whole cell preparations of B. nodosus in inducing protective immunity against homologous footrot challenge. The recombinant-produced fimbriae are also effective therapeutically in accelerating the rate of healing of pre-existing footrot lesions. These results confirm that the structural subunit of the fimbrial strand is a primary protective antigen against footrot, and demonstrate the practicality and potential of recombinant DNA approaches to the development of new vaccines against B. nodosus and other Type 4 fimbriate pathogens.


Sep 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·H TowbinJ Gordon
Mar 1, 1975·Journal of General Microbiology·T M Skerman
Jan 1, 1975·Annual Review of Microbiology·J C Ottow
Apr 1, 1986·Australian Veterinary Journal·D J StewartI J O'Donnell
Jan 1, 1973·Journal of Comparative Pathology·J R Egerton
Apr 1, 1971·Journal of Comparative Pathology·J R Egerton, D S Roberts
Nov 1, 1970·Australian Veterinary Journal·J R Egerton, D H Burrell
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Jan 1, 1983·Journal of General Microbiology·D Every, T M Skerman
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Nov 1, 1983·Australian Veterinary Journal·P D ClaxtonJ R Egerton
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Jan 1, 1994·Biotechnology Advances·L A Babiuk, A A Potter
Jan 1, 1994·Micron : the International Research and Review Journal for Microscopy·M R Mott, W Reilly
Dec 30, 1999·Veterinary Immunology and Immunopathology·H W RaadsmaA M Crawford
Aug 1, 1998·Journal of Controlled Release : Official Journal of the Controlled Release Society·A K WalduckR Prankerd
Apr 22, 2004·Nature Reviews. Microbiology·Lisa CraigJohn A Tainer
Jan 12, 1993·Journal of Animal Breeding and Genetics = Zeitschrift Für Tierzüchtung Und Züchtungsbiologie·H W RaadsmaS C Brown
Jun 1, 1990·Australian Veterinary Journal·L J MooreJ R Egerton
Feb 1, 1991·Australian Veterinary Journal·D J StewartJ H Dufty
Apr 1, 1993·Australian Veterinary Journal·C L SchwartzkoffP A Hoyne
Aug 2, 2005·Vaccine·Sergio RegodónDavid Pozo
Dec 3, 2014·Vaccine·Vidya BhardwajRichard Whittington
Jul 27, 2002·Annual Review of Microbiology·J S Mattick
Apr 17, 2014·Vaccine·Om DhungyelRichard Whittington
Jan 1, 2011·Genes·Saul BurdmanLeonardo De La Fuente
Oct 1, 1993·Immunology and Cell Biology·T J O'MearaH W Raadsma

Related Concepts

Antigens, Bacterial
Bacterial Vaccines
Recombination Joint
Foot Rot
Genes, Bacterial
Bacterial Pilus
Pseudomonas aeruginosa
Dall Sheep

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