PMID: 1202594Dec 11, 1975Paper

Protection of the intestinal mucosa during ischaemia by intraluminal perfusion

Research in Experimental Medicine. Zeitschrift Für Die Gesamte Experimentelle Medizin Einschliesslich Experimenteller Chirurgie
V MirkovitchJ W Robinson

Abstract

The function of the intestinal mucosa immediately after one hour's ischaemia was examined by means of tests in vivo and in vitro. During the ischaemia, the intestinal loop was perfused with media of different compositions, in an attempt to assess which provided the best protection of the epithelium from the deleterious effects of the ischaemia. The absorption of water, ions and glucose was then monitored in vivo, and the uptake of phenylalanine and beta methyl-glucoside by slices of mucosa was determined in vitro. The unprotected mucosa loses all active transport capacity in vitro following one hour's ischaemia, and is the site of a pronounced loss of water and ions into the lumen in vivo. Glucose absorption in vivo is also abolished. If the loop is perfused during the ischaemia with glucose-containing Krebs bicarbonate buffer, much of the transport capacity in vitro is retained; the loss of ions and water is prevented, and glucose absorption in vivo occurs. Perfusion during the ischaemia with other media, such as isotonic mannitol, Krebs bicarbonate buffer, or Ringer-lactate solution, results in a marked protection of the mucosa, in comparison with the unperfused loop, but the effects are not as pronounced as those of the gluc...Continue Reading

References

Jan 1, 1966·Naunyn-Schmiedebergs Archiv für Pharmakologie und experimentelle Pathologie·J W RobinsonV Mirkovitch
Apr 1, 1972·The Journal of Clinical Investigation·D A SaltzmanJ S Fordtran
Sep 1, 1972·Archives of Surgery·A H McArdleF N Gurd

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Citations

Jul 22, 1976·Research in Experimental Medicine. Zeitschrift Für Die Gesamte Experimentelle Medizin Einschliesslich Experimenteller Chirurgie·V MirkovitchF Cobo
Jan 1, 1987·Research in Experimental Medicine. Zeitschrift Für Die Gesamte Experimentelle Medizin Einschliesslich Experimenteller Chirurgie·V Mirkovitch, B Winistörfer
Jan 1, 1980·Research in Experimental Medicine. Zeitschrift Für Die Gesamte Experimentelle Medizin Einschliesslich Experimenteller Chirurgie·J W RobinsonV Mirkovitch
Apr 1, 1995·Journal of Pharmacological and Toxicological Methods·R L OberleD A Krummel
Jun 1, 1981·Gut·J W RobinsonF Saegesser
Jan 1, 1990·Journal of Investigative Surgery : the Official Journal of the Academy of Surgical Research·H FujiwaraW W Johnson
Jan 1, 1988·Scandinavian Journal of Plastic and Reconstructive Surgery and Hand Surgery·R W SmithD M Davies

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