Protection of the rat gastric mucosa against aspirin injury by arachidonic acid: a dietary prostaglandin precursor fatty acid

European Journal of Clinical Investigation
A TarnawskiH Gergely

Abstract

We studied aspirin-induced injury to the gastric mucosa in control rats pretreated with a solubilizer, pluronic F-68 (PL), and in rats pretreated with solubilized arachidonic acid (AA). Fasted male rats were pretreated intragastrically with 1 ml of either pluronic or AA and 1 h later acidified ASA (1 ml suspension of 200 mg kg-1 body weight) was administered intragastrically. Grossly apparent mucosal lesions developed 1 h after aspirin in pluronic-pretreated rats, but were significantly reduced in AA-pretreated rats. Histology, scanning and transmission electron microscopy demonstrated that AA pretreatment did not prevent aspirin-induced initial damage to the surface epithelium but did significantly reduce extent of aspirin-induced deep mucosal necrosis at 1, 4 and 18 h after aspirin. Initial aspirin-induced surface epithelial damage was rapidly restituted by two distinct types of re-epithelialization - vertical and horizontal. While the vertical type of re-epithelialization has been reported previously as the first stage of mucosal repair following injury by various noxious agents such as concentrated ethanol, the horizontal type of re-epithelialization, which is described for the first time in this paper, seems to be specific...Continue Reading

References

Feb 1, 1986·Digestive Diseases and Sciences·F E SilversteinD S Levine
Apr 1, 1988·Gastroenterology·H W GrantJ J Misiewicz
Jan 1, 1988·Gastroenterology·P J Oates, J P Hakkinen
Sep 1, 1986·Prostaglandins, Leukotrienes, and Medicine·R W KellyR F Seamark
Jan 1, 1986·Digestive Diseases and Sciences·T WittmannJ F Grenier
Feb 1, 1986·Digestive Diseases and Sciences·D E Wilson
Nov 1, 1985·Digestive Diseases and Sciences·J I Isenberg
Nov 1, 1985·Digestive Diseases and Sciences·G L Eastwood
Oct 1, 1973·The American Journal of Digestive Diseases·C J Pfeiffer, J Weibel
Jun 8, 1967·The New England Journal of Medicine·H W Davenport

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Citations

Jun 1, 1995·Journal of Gastroenterology·J StachuraW Domschke
Dec 20, 2005·The Journal of Surgical Research·Emily K RobinsonDavid W Mercer
Jan 6, 2016·Journal of Neurogastroenterology and Motility·Seungil Ro
Mar 1, 1994·Journal of Gastroenterology and Hepatology·F I Tovey

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