PMID: 6538536Mar 1, 1984Paper

Protection with butylated hydroxytoluene and other compounds against intoxication and mortality caused by hexachlorophene

Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association
J P HanigS Krop

Abstract

The antioxidants butylated hydroxytoluene (BHT) and ethoxyquin protected rats against intoxication and mortality normally produced by hexachlorophene (HCP, 100 mg/kg). BHT also prevented the elevation of cerebrospinal fluid pressure, a central nervous system effect of HCP poisoning. In addition, both phenobarbital and SKF-525A protected against HCP poisoning, with the barbiturate also offering significant protection against triethyltin. L-Ascorbic acid, vitamin E, N,N-diphenyl-p-phenylenediamine and reduced and oxidized glutathione over a range of doses were ineffective in preventing HCP lethality. The protective effect of phenobarbital against HCP and triethyltin intoxication further supports existing evidence of a common or similar mechanism of toxic action for these two structurally dissimilar compounds.

References

Feb 1, 1977·Food and Cosmetics Toxicology·J P HanigS Krop
Jun 1, 1976·Proceedings of the Society for Experimental Biology and Medicine·J P HanigS H Colson
May 1, 1976·Journal of Neurochemistry·E A Lock
Jul 15, 1974·Biochemical Pharmacology·A J GandolfiD R Buhler
Mar 10, 1972·Biochemical and Biophysical Research Communications·W Cammer, C L Moore
Nov 1, 1969·Food and Cosmetics Toxicology·J G Nievel
Feb 1, 1968·The Biochemical Journal·M S Rose, W N Aldridge
Nov 1, 1955·The Biochemical Journal·W N ALDRIDGE, J E CREMER

❮ Previous
Next ❯

Related Concepts

Related Feeds

CSF & Lymphatic System

This feed focuses on Cerebral Spinal Fluid (CSF) and the lymphatic system. Discover the latest papers using imaging techniques to track CSF outflow into the lymphatic system in animal models.