PMID: 2510643Jul 1, 1989Paper

Protective action of cicletanine on the vascular walls in stroke-prone spontaneously hypertensive rats

Archives des maladies du coeur et des vaisseaux
M M RuchouxY Lhuintre

Abstract

In previous works, cicletanine has proven a protective effect on tissues in stroke-prone spontaneously hypertensive rats. The mechanism by which cicletanine lessens the tissue lesion incidence may be explained by the direct vascular effect of increased prostacyclin synthesis and by interaction with various agents mobilizing intracellular. Ca2+ ions. Histological so as to ultrastructural studies of the capillaries and small arteries were performed, specially on those of brain, kidney, heart, and choroid. Method : 36 SHR-SP/A 3N Iffa Credo rats aged 11 weeks were divided into 3 groups. Their drinking water was added with 1 p. 100 NaCl in. Group I was a control group, groups II and III were orally treated with cicletanine, respectively 100 and 150 mg/Kg. Systolic blood pressure, body weight, survival were reported. After 7 weeks of treatment the surviving rats were sacrificed. the control group arterioles showed endoluminal debris with intimal proliferation and a large disorganisation of the media with adventitial fibrosis. The treated groups only showed a slight oedema of the subendothelial space in ultrastructure with no intimal proliferation and no muscle coat disorganisation or proliferation. even though the decrease in blood ...Continue Reading

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