Protective action of timolol in acute myocardial ischemia

European Journal of Pharmacology
A M LeferG H Osman

Abstract

Timolol, a beta-adrenoceptor blocking agent with little or no cardiodepressant activity, was studied in acute myocardial ischemia in cats. Timolol, at a dose of 25 mug/kg, blocked 75 to 80% of the cardiac response to isoproterenol. This dose also significantly reduced heart rate in cats subjected to acute myocardial ischemia by ligation of the left coronary artery. Timolol significantly prevented the spread of ischemic damage in the myocardium as assessed by (a) curtailing the increase in plasma creatine phosphokinase (CPK) activity, (b) preventing the loss of CPK from the ischemic portion of the myocardium, and (c) restoring the elevated S-T segment of the electrocardiogram toward normal. Timolol did not significantly retard the increase in fragility of lysosomes in ischemic myocardial tissue. The mechanism of the protective effect to timolol on the ischemic myocardium appears to be via reducing myocardial oxygen demand by decreasing heart rate.

References

Jan 1, 1988·Virchows Archiv. A, Pathological Anatomy and Histopathology·G GreveL Stangeland
Jan 22, 1982·European Journal of Pharmacology·E F SmithA M Lefer
Jun 24, 1986·European Journal of Pharmacology·N LavanchyA Rossi
Mar 24, 1992·European Journal of Pharmacology·Y NasaY Abiko
May 19, 1993·European Journal of Pharmacology·A N HoqueY Abiko
Jan 1, 1982·Prostaglandins, Leukotrienes, and Medicine·S Okamatsu, A M Lefer
Jun 1, 1984·Journal of the American College of Cardiology·H HammermanE Braunwald
Oct 1, 1985·Annals of Emergency Medicine·W H Spivey, C M Lathers
Aug 1, 1987·Journal of Clinical Pharmacology·C M Lathers, W H Spivey
Jan 1, 1984·Acta Medica Scandinavica. Supplementum·H J Jürgensen
Feb 1, 1985·Scandinavian Journal of Clinical and Laboratory Investigation·L StangelandA M Bakken

Citations

Mar 1, 1976·Progress in Cardiovascular Diseases·G AhumadaB E Sobel
Aug 1, 1975·The American Journal of Cardiology·J Lekven
Jan 1, 1976·The Journal of Surgical Research·A BeardsleyA M Lefer
Nov 1, 1973·Annals of Internal Medicine·P R Maroko, E Braunwald
Apr 1, 1973·The American Journal of Cardiology·W E Shell, B E Sobel
Dec 1, 1966·American Heart Journal·B L Pentecost, W G Austen

Related Concepts

Tissue Membrane
Bradycardia
Diastolic Blood Pressure
Myocardium
Myocardial Ischemia
Left Coronary Artery Structure
Fragility
Propanolamines
Lysosomes
Sinus Node Artery

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